In this study, a fast, concise and reliable ultra-high performance liquid chromatography-fluorescence (UHPLC/FLD) detection method for simultaneous quantification of avermectins (AVMs), including avermectin (AVM), ivermectin (IVM), emamectin (EMM), moxidectin (MOX) doramectin (DOR) in six aquatic foods was established. Based on the QuEChERS pretreatment method, samples were extracted with 0.2% ...

Ivermectin was first approved for human use as an endectocide in the 1980s. It remains one of most important global health medicines history and has recently been shown to exert vitro activity against SARS-CoV-2. However, macrocyclic lactone family compounds not previously evaluated The present study aims at comparing their anti-viral relevant pulmonary cell lines vitro. Here, antiviral avermec...

The article shows the achievements of last decades, which led to emergence new
 directions in manufacture medicines, revision and reassessment a number theoretical
 positions traditional techniques. most significant influence on development dosage forms
 was establishment dependence therapeutic effect medicinal substances not only the
 chemical structure physiological activi...

The γ-butyrolactone autoregulator receptor has been shown to control secondary metabolism and/or morphological differentiation across many Streptomyces species. Streptomyces avermitilis produces an important anthelmintic agent (avermectin) and two further polyketide antibiotics, filipin and oligomycin. Genomic analysis of S. avermitilis revealed that this micro-organism has the clustered putati...

The level of activity of avermectin B O-methyltransferase, the enzyme which catalyzes the conversion of avermectin B components to avermectin A components, was analyzed in a series of "Streptomyces avermitilis" mutants selected for increased production of the avermectins. In all of the mutants, increased avermectin production was accompanied by increased avermectin B O-methyltransferase activit...

Streptomyces avermitilis is an important bacterial species used for industrial production of avermectins, a family of broad-spectrum anthelmintic agents. We previously identified the protein SAV576, a TetR family transcriptional regulator (TFR), as a downregulator of avermectin biosynthesis that acts by controlling transcription of its major target gene SAV575 (which encodes cytochrome P450/NAD...