Photodynamic therapy is considered investigational when used in combination with one or more of the anti-vascular endothelial growth factor therapies (anti-VEGF), i.e., pegatanib (Macugen), ranibizumab (Lucentis), bevacizumab (Avastin), aflibercept (EyleaTM) as a treatment of CNV associated with agerelated macular degeneration, chronic central serous chorioretinopathy, choroidal hemangioma, pat...

Methods:Ophthalmologists prospectively followed patients, who received IVT injection treatment for AMD including Macugen®, Lucentis®, and Avastin® at ophthalmic clinical centers in Europe, and determined outcomes of interest as clinically appropriate up to two years. Main outcomesincluded endophthalmitis, retinal detachment, vitreous hemorrhage, retinal tear, traumatic cataract, and increased i...

Trehalose, a disaccharide of glucose, has been reported to accumulate in many organisms that can withstand extended periods of inanimation. Since this discovery, the properties of trehalose have been examined extensively to understand its role and abundance in nature. The unique features of this sugar became clearer with each new finding which demonstrated its ability to sustain and preserve a ...

OBJECTIVES To report systemic and ocular complications within a year of intravitreal injection of bevacizumab (Avastin) in ocular neovascularisation. METHODS The quasi-experimental (randomized without control) study was carried out at the Eye Department of Abbasi Shaheed Hospital, Karachi, from July 2008 to June 2010. It comprised 150 patients selected from the outpatient department with ocul...

purpose : to review the effectiveness and safety of perioperative injection of bevacizumab in vitrectomy for proliferative diabetic retinopathy (pdr) methods : a literature search of all english articles from the medline and scopus databases was performed. original articles, case reports and letters were included. results : nineteen, 3 and 5 studies reported preoperative, intraoperative and pos...

Bevacizumab (Avastin) has rapidly gained status as a broadly active agent for malignancies of several different histologies in adults. This activity has spawned a range of uses in pediatrics for both oncologic and non-oncologic indications. Early analyses indicate that pediatric cancers exhibit a spectrum of responses to bevacizumab that suggest its activity may be more limited than in adult on...

Platelet-activated serum (PAS) was collected from rabbits. This contains high concentrations of growth factors, including vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF)-BB, and transforming growth factor-beta (TGF-β). PAS was injected into the knee joints of Japanese White rabbits subjected to anterior cruciate ligament transection (ACL-T) to investigate its th...

Bevacizumab (Avastin, Genentech) is a recombinant humanised, full length, antiVEGF monoclonal antibody that binds all isoforms of VEGF-A. It has been shown to prolong survival of patients with advanced colon cancer when combined with 5-fluorouracil. In this report, we describe the effect of bevacizumab in two patients with choroidal neovascularisation (CNV) secondary to pathological myopia, whi...

Central retinal vein occlusion in young people is a rare entity. Here we present two cases of central retinal vein occlusion in young women using oral contraceptive pills. We found no other systemic problems and all routine investigations were within normal limits. The cases were managed with further avoidance of oral contraceptives and intravitreal injections of Bevacizumab (Avastin) to reduce...