Context Non-swelling autoimmune pancreatitis with multiple pancreatic pseudocysts is very rare. Case report A Seventy-five-year-old man was referred to our hospital for further examination of multiple pancreatic cysts with nodules detected by computed tomography. Endoscopic ultrasound examination showed a pancreatic cyst with a nodule (6.3 mm in diameter) in the pancreatic head and another panc...

CONTEXT Autoimmune pancreatitis is a benign inflammatory disease of the pancreas which mimics pancreatic malignancy both clinically and radiologically. Autoimmune pancreatitis is presented as a diffuse enlargement of the pancreas and as a diffuse irregular narrowing of the main pancreatic duct. CASE REPORT We report the endoscopic-ultrasound-guided (EUS-guided) fine needle aspiration (FNA) cy...

Background. Autoimmune pancreatitis (AIP) often mimics pancreatic cancer. The diagnosis of both conditions is difficult preoperatively let alone when they coexist. Several reports have been published describing pancreatic cancer in the setting of AIP. Case Report. The case of a 53-year-old man who presented with abdominal pain, jaundice, and radiological features of autoimmune pancreatitis, wit...

A 70-year-old man was referred for evaluation of mild epigastric discomfort with tiredness. He had no particular medical history and admitted drinking two glasses of wine a day. Biology showed a small increase in CRP and pancreatic enzymes (lipases and amylases). Ultrasound examination was negative for gallstone or biliary dilatation. Abdominal contrast-enhanced CT showed a sharply delineated e...

Histopathology of type 2 AIP The pancreas of patients with type 2 AIP is often only focally involved. The region that seems to be most often affected is the pancreatic head including the pancreatic portion of the distal bile duct. As in type 1 AIP, the outstanding histologic feature is a periductal lymphoplasmacytic infiltrate usually affecting some or all of the medium sized ducts (Figure 1). ...

In 1995 when Yoshida et al. coined the term “autoimmune pancreatitis” they listed several serologic and imaging features that helped them recognize the entity (10). These features formed the basis for the first diagnostic criteria proposed by the Japan Pancreas Society in 2002 (9). In these reports hypergammaglobulinemia and nonspecific markers such as rheumatoid factor and antinuclear antibodi...

Autoimmune pancreatitis (AIP) is an unusual type of chronic pancreatitis having an underlying autoimmunity mechanism. Lymphoplasmacytic infiltration and fibrosis on histology, and elevated IgG levels or detected autoantibodies on laboratory data support the concept of AIP. Periductal lymphoplasmacytic infiltration and fibrosis, its preferential occurrence in the pancreatic head, and venulitis c...

Purpose Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis based on an autoimmune inflammatory process (1, 2). Up to 5% of all cases of chronic pancreatitis are thought to be AIP (2). It may be focal or diffuse. Typical cross sectional imaging characteristics for AIP include enlargement of the affected parts of the gland, irregular narrowing of the main pancreatic duct and red...

Autoimmune pancreatitis is part of the spectrum of IgG4-associated diseases. Its diagnostic criteria and histological subtypes have been formally proposed recently and although based on current data it has been suggested that there are differences in clinical presentation among populations, more research is needed to properly establish if this heterogeneity exists. In this paper, we describe 15...

Although the autoimmune regulator (Aire) knockout (KO) mouse model has been reported to present various organ-specific autoimmune diseases depending on genetic background, autoimmune pancreatitis in mice of BALB/c background has not yet been reported. Here, we report that Aire KO mice with BALB/cAnN background showed significant lymphoid cell infiltration in the pancreas and stomach. To examine...