Increased plasma atrial natriuretic peptide levels accompany the expansion of effective plasma volume in diabetic patients. Atrial natriuretic peptide has a deleterious effect on the pathogenesis of diabetic nephropathy by increasing renal plasma flow and glomerular filtration rate. Angiotensin converting enzyme inhibitors decrease plasma atrial natriuretic peptide levels. We aimed to show the ...

The effect of angiotensin II (5, 10, and 20 ng/kg/mln) on blood pressure and on the plasma concentrations of aldosterone was studied in six healthy men with and without the concomitant administration of synthetic human atrial natriuretic peptide given 1) as an i.v. bolus of 25 fig followed by a 6-hour infusion of 25 /xg/hr or 2) as an i.v. bolus of 175 /xg followed by a 6-hour infusion of 100 j...

1 De Bold AJ, Borenstein HB, Veress AT, et al. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extracts in rats. Life Sci 1981; 28:89-94 2 Adnot S, Chabrier PE, Brun-Buisson C, et al. Atrial natriuretic factor attenuates the pulmonary pressor response to hypoxia. J Appl Physiol 1988; 65:1975-88 3 McKenzie JC, Tanaka I, Inagami T, et al. Alterations in atria...

We isolated the human C-type natriuretic peptide gene and identified the peptide in the brain. The human C-type natriuretic peptide gene appeared to be composed of at least two exons and one intron. In the 5'-flanking region, there is an array of cis elements (an inverted CCAAT box, two GC boxes, and a cyclic AMP response element-like sequence) that is not present in upstream sequences of the a...

1. Adrenomedullin is a recently discovered vasodilating and natriuretic peptide whose physiological and pathophysiological roles remain to be established. Like atrial natiuretic peptide adrenomedullin is expressed in the left ventricle. Ventricular expression of atrial natriuretic peptide is known to be markedly increased by volume or pressure overload. In this study we investigated whether ven...

This study was carried out to examine the effects of atrial natriuretic peptide on coronary collateral blood flow. Studies were performed in nine adult mongrel dogs 3.4 months after embolic occlusion of the left anterior descending coronary artery had been performed to stimulate collateral vessel growth. At the time of study the anterior descending coronary artery was cannulated to allow estima...

Natriuretic peptides (NPs), such as atrial natriuretic peptide (ANP), C-type natriuretic peptide (CNP), and adrenomedullin (ADM), are endogenous vasodilators acting via specific receptors. This study addressed the question of how pulmonary artery (PA) responses to these peptides and the gene expression of their receptors are modulated in pulmonary hypertension rat models exposed to chronic hypo...

Lee, Sook Jeong, Sung Zoo Kim, Xun Cui, Suhn Hee Kim, Kyung Sun Lee, Yu Jeong Chung, and Kyung Woo Cho. C-type natriuretic peptide inhibits ANP secretion and atrial dynamics in perfused atria: NPR-B-cGMP signaling. Am. J. Physiol. Heart Circ. Physiol. 278: H208–H221, 2000.— The purpose of the present experiments was to define the role of C-type natriuretic peptide (CNP) in the regulation of atr...

conclusions the results of the current study suggested that spinal anesthesia plus intravenous patient-controlled analgesia have the most favorable cardiac effects regarding postoperative levels of pro-bnp. results there was no difference between three groups for basic characteristics and variables and baseline pro-bnp levels; however, postoperative pro-bnp levels in groups a, b, and c were res...