UNLABELLED Modeled attenuation correction (AC) will be necessary for combined PET/MRI scanners not equipped with transmission scanning hardware. We compared 2 modeled AC approaches that use nonrigid registration with rotating (68)Ge rod-based measured AC for 10 subjects scanned with (18)F-FDG. METHODS Two MRI and attenuation map pairs were evaluated: tissue atlas-based and measured templates....

Brightfield and fluorescent imaging of whole brain sections are fundamental tools of research in mouse brain study. As sectioning and imaging become more efficient, there is an increasing need to automate the post-processing of sections for alignment and three dimensional visualization. There is a further need to facilitate the development of a digital atlas, i.e. a brain-wide map annotated wit...

Although much is known about the pathophysiological cellular processes underlying heart disease, little is known about how the heart remodels structurally and functionally during the development of disease, and how particular presentations of disease fit into the spectrum of functional manifestations across patient groups. If clinicians were able to map the structure and function of the heart i...

Receptor tyrosine kinases (RTKs) and the signaling cascades that they trigger play central roles in diverse developmental processes. We describe the capacity to follow the active state of these signaling pathways in situ. This is achieved by monitoring, with a specific monoclonal antibody, the distribution of the active, dual phosphorylated form of MAP kinase (ERK). A dynamic pattern is observe...

The U.S. Bureau of the Census Urban Atlas project in the 1970s was an attempt to provide the public access to maps of selected census statistics. The technology of the time, however, only permitted a very limited number of census characteristics to be displayed in an atlas and at only one census geography—census tracts. The atlases also had limited availability and accessibility. Today the Worl...

In geography new measuring techniques and imaging modalities have led to a huge amount of distributed data requiring new digital processing techniques. Environmental monitoring programs and analysis of global change in geography, meteorology, and climatology require an interdisciplinary usage of knowledge about the ecological system earth. Until recently the traditional atlas has been the prima...

Segmentation of organs at risk (OARs) remains one of the most time-consuming tasks in radiotherapy treatment planning. Atlas-based segmentation methods using single templates have emerged as a practical approach to automate the process for brain or head and neck anatomy, but pose significant challenges in regions where large interpatient variations are present. We show that significant changes ...

eQTL: expression Quantitative Trait Loci; GAD: Genetic Association Database; GtEx: Genotype-tissue Expression; HapMap: Haploid Map; HGNC: Human Genome Nomenclature Committee; HPRD: Human Protein Reference Database; HPA: Human Protein Atlas; MOPED: Model Organism Protein Expression Database; PheGenI: Phenotype-Genotype Integrator; ORF: Open Reading Frame; RefSeq: Reference Sequence; SNP: Single ...

PURPOSE The authors present a fully automatic algorithm for the segmentation of the prostate in three-dimensional magnetic resonance (MR) images. METHODS The approach requires the use of an anatomical atlas which is built by computing transformation fields mapping a set of manually segmented images to a common reference. These transformation fields are then applied to the manually segmented s...