OBJECTIVE Although the metabolic syndrome (MS) is associated with increased cardiovascular risk, its relationship with atherosclerotic progression is less well defined. We sought to determine whether the MS predicts angiographic progression of coronary heart disease in a cohort of postmenopausal women. METHODS AND RESULTS A total of 309 postmenopausal women entered the Estrogen Replacement an...

Although controversy continues, the preponderance of evidence indicates that estrogen replacement therapy favorably influences the risk of coronary heart disease in postmenopausal women. It remains uncertain how this effect is mediated and whether the cyclic addition of a progestin may influence adversely an estrogen-related cardioprotective effect. We investigated the influence of sex hormone ...

OBJECTIVE This study aims to present methods and baseline data from the Early versus Late Intervention Trial with Estradiol (ELITE), the only clinical trial designed to specifically test the timing hypothesis of postmenopausal hormone therapy (HT). The timing hypothesis posits that HT effects depend on the temporal initiation of HT relative to time since menopause. METHODS ELITE is a randomiz...

conclusions we suggest that regular aerobic exercise can favorably alter the inflammatory profile, which is a known risk factor in breast cancer development, in postmenopausal women. patients and methods this study was a randomized controlled trial. we randomly assigned 41 postmenopausal, sedentary women aged 50 to 74 to either an exercise or a control group. the intervention involved facility-...

BACKGROUND Abnormal glucose tolerance (AGT; diabetes or impaired glucose tolerance) is associated with increased risk of cardiovascular disease, especially in women. Cardiovascular disease rates in women increase after menopause. The Women's Health Initiative found that postmenopausal hormone therapy (PHT) increased the risk of cardiovascular disease and that effects in diabetic women did not d...

background: low bone mass is a major health problem in postmenopausal women.there is no general agreement regarding relationship between serum level of lipidsand bone mineral density.objective: this study was carried out to investigate the association between lipidprofile and bone mineral density (bmd) in postmenopausal women in yazd, iran.materials and methods: this cross-sectional study was p...

OBJECTIVE The objective of the present study was to examine the relationship between plasma alkyresorcinol (AR) concentrations, which are biomarkers of whole-grain intake, and atherosclerotic progression over 3 years in postmenopausal women with coronary artery disease. DESIGN Plasma AR concentrations were measured by a validated GC-MS method in fasting plasma samples. Atherosclerosis progres...

The effects of estrogens on reproductive tissues and climacteric symptoms are unambiguous. However, their effects on other tissues and, in particular, the cardiovascular system remain controversial. In general, premenopausal women are protected from coronary heart disease (CHD) compared with aged-matched men but this ;female protection' appears to be lost after menopause, suggesting beneficial ...

BACKGROUND Higher intakes of fish and n-3 fatty acids are associated with a reduced risk of cardiovascular events and mortality. However, limited data exist on the effect of fish intake on actual measures of progression of coronary artery atherosclerosis. OBJECTIVE The aim was to examine the association between fish intake and the progression of coronary artery atherosclerosis in women with c...

Multiple observational studies have reported that postmenopausal women who use estrogen have a lower rate of coronary heart disease (CHD) events than women who do not use estrogen (1). Meta-analyses of these epidemiologic findings suggest a 35% to 50% reduction in risk of coronary disease among women using estrogen compared to nonusers (2,3). These findings are supported by plausible biologic m...