Atrial fibrillation (AF) is the most common arrhythmia in clinical practice, with an estimated prevalence of 0.4% to 1% in the general population, increasing with age to 8% in those above 80 years. The recognised risk factors for developing AF include age, structural heart disease, hypertension, diabetes mellitus or hyperthyroidism. However, the mechanisms underlying the initiation of AF in pat...

Obstructive sleep apnea (OSA) is a sleep breathing disorder affecting millions of people worldwide. It is medically significant because it has been shown to be a risk factor for the development of various cardiac pathologies, including atrial fibrillation (AF). Several studies have shown a correlation between OSA and AF and disparities of OSA occurrence in different ethnic and racial groups. We...

Paeonia lactiflora root (baishao in Chinese) is a commonly used herb in traditional Chinese medicine (TCM). Paeoniflorin (PF) and albiflorin (AF) are two major active constituents of P. lactiflora. In this paper, we aimed to investigate the hematopoietic effects of PF and AF on myelosuppression mice induced by radiotherapy and to explore the underlying mechanism. The finding indicated that PF a...

AIMS To identify intracardiac hemostasis or fibrinolysis abnormalities, which are associated with atrial fibrillation (AF) and increase the risk of thromboembolism. PATIENTS AND METHODS Patient group consisted of 24 patients with AF and control group included 14 individuals with other supraventricular tachycardia undergoing transcatheter radiofrequency ablation. Blood samples were drawn from ...

BACKGROUND AND PURPOSE Atrial fibrillation (AF) is an independent risk factor for stroke. Recent studies have demonstrated that the CHA(2)DS(2)-VASc scheme is useful for selecting patients who are truly at low risk. The goal of the present study was to compare the risk of ischemic stroke among AF patients with a CHA(2)DS(2)-VASc score of 0 (male) or 1 (female) with those without AF. METHODS T...

Estrogen receptor-alpha contains two transactivation functions, a weak constitutive activation function (AF-1) and a hormone-dependent activation function (AF-2). AF-2 works by recruiting a large coactivator complex, composed of one or more p160s, CREB-binding protein (CBP)/p300, and P/CAF (p300 and CBP-associated factor), via direct contacts with the p160s. We report here that independent AF-1...

ATRIAL FIBRILLATION (AF) IS one of the most common arrhythmias among critically ill patients. Previous studies have demonstrated that 6% to 20% of patients with severe sepsis develop newonset AF, suggesting that severe sepsis may be a predisposing factor for new-onset AF. Although chronic AF is a major contributor to long-term disability and mortality, the relationship of new-onset AF in severe...

BACKGROUND Central nervous system (CNS) complications are increasingly noted in liver transplanted (LTx) hereditary transthyretin amyloid (ATTRm) amyloidosis patients; this suggests that the increased survival allows for intracranial ATTRm formation from brain synthesized mutant TTR. However, atrial fibrillation (AF), a recognised risk factor for ischemic CNS complications, is also observed aft...

Atrial fibrillation (AF) is the most common form of arrhythmia in the world. As the population ages, it is estimated that the prevalence of AF will increase by 2.5 fold in the next 50 years.1 At the same time, diabetes has become a pandemic disease in the western world as well as in developing countries. Independent risk factors for chronic AF include hypertension, heart failure, valvular heart...

Catheter ablation is an important treatment modality for management of Atrial Fibrillation (AF). AF a responsible factor in the pathophysiology Heart Failure with Preserved Ejection Fraction (HFpEF). However, relationship between and Right Ventricular (RV) dysfunction has not been completely distinguished.