BACKGROUND The pathophysiology of asthma involves the action of inflammatory/allergic lipid mediators formed following membrane phospholipid hydrolysis by phospholipase A(2) (PLA(2)). Cysteinyl leukotrienes are considered potent inducers of bronchoconstriction and airway remodelling. Ovalbumin (OVA) induced bronchoconstriction in rats is associated with increased secretory PLA(2) (sPLA(2)) acti...

backgroundasthma is the most chronic inflammatory disorder of the airways in children and asthmatic patients can experience cardiac dysfunction, pulmonary hypertension and finally cor pulmonale later in life. we aimed to investigate right ventricular (rv) functions in asthmatic children by conventional and tissue doppler echocardiography (tde).materials and methods pulmonary function tests, con...

Activity of Protein Synthesis by the Intestine: Felix Fri ed berg ..............................314 Lipoid Substance in the Cells of Proximal Convoluted Tubules of the Kidneys of Young Rats on a Cholinedeficient Diet: W. Stanley Hartroft and C. H. Best... 315 Quick Decline of Orange Trees-A Virus Disease: J. M. Wallace and H. S. Fawcett ................. 315 A Quantitative Study of the Compleme...

BACKGROUND Adrenal neuroendocrine plays an important role in asthma. The activity of the sympathoadrenal system could be altered by early life events. The effects of maternal asthma during pregnancy on the adrenal medulla of offspring remain unknown. METHODOLOGY/PRINCIPAL FINDINGS This study aims to explore the influence of maternal asthma during pregnancy on the development and function of a...

OBJECTIVES Few nationwide population-based studies have examined the burden of asthma during pregnancy. Here, we investigated the burden and medical treatment of asthma during pregnancy requiring healthcare utilisation in South Korea. DESIGN Cohort study. SETTING Nationwide insurance claims database. PARTICIPANTS A total of 1,306,281 pregnant women who delivered in South Korea in 2009-201...

It is known that the prevalence of gastroesophage-al reflux disease (GERD) in asthmatic patients is high. Although an endoscopic diagnosis of GERD based on the established Los Angeles (LA) classification requires the detection of erosive mucosal breaks, there are patients with GERD who have prominent erythema of the esophageal membrane without erosive mucosal breaks. Non-erosive mucosal change ...

Asthma is a multifactorial disease in which many factors play a role in its development and exacerbations. Viral infections are known to be the main cause of asthmatic exacerbations and are often the first manifestation of asthma in preschool age. However, there is much evidence suggesting a role of viral infections even in asthma development. Respiratory Syncytial Virus (RSV). has been first a...