BACKGROUND Budesonide inhalation suspension and the leukotriene receptor antagonist montelukast have demonstrated efficacy in children with mild persistent asthma, but comparative long-term studies in young children are needed. OBJECTIVE To compare the long-term efficacy and safety of budesonide inhalation suspension and montelukast. METHODS After a run-in period, children 2 to 8 years old ...

BACKGROUND Asthma exacerbation is an episode of (sub)acute worsening of asthmatic symptoms. Exacerbation may depend on environmental factors. OBJECTIVE The present study investigated emergency calls for asthma exacerbation in children, analysing: i) their trend over the course of time; and ii) their possible relationship with environmental factors, including pollen count, meteorological param...

Reslizumab, an anti-interleukin-5 monoclonal antibody, significantly reduces exacerbation frequency and improves lung function, asthma control and quality of life in adults with severe eosinophilic asthma, as demonstrated in Phase III studies. This secondary analysis assessed reslizumab's efficacy in patients receiving baseline treatment per Global Initiative for Asthma (GINA) Step 4 and Step 5...

Symptomatic differences and the impact of gastroesophageal reflux disease (GERD) have not been clarified in patients with asthma and chronic obstructive pulmonary disease (COPD). The purpose of this study is to assess the differences of GERD symptoms among asthma, COPD, and disease control patients, and determine the impact of GERD symptoms on exacerbation of asthma or COPD by using a new quest...

PURPOSE To investigate the clinical and cost effectiveness of switching real-life asthma patients from other types of inhalers to the Easyhaler(®) (EH) for the administration of inhaled corticosteroids (ICS). PATIENTS AND METHODS Historical, matched-cohort study of 1,958 asthma patients (children and adults) treated in UK primary-care practices, using data obtained from the Optimum Patient Ca...

Introduction The Spanish Pediatrics Emergency Society (SEUP) determined two assistance quality indicators for attendance of asthma exacerbation in Emergency Departments (ED): 1. A validated-score severity evaluation at discharge (standard 100%) 2. Respiratory rate and oxygen saturation registration on the medical record of the patients with chief complaint of breathing difficulty. In April 2012...

Background Emphysema is a distinct feature for classifying COPD, and smoking history (≥10 pack-years) is one of several newly proposed criteria for asthma-COPD overlap (ACO). We studied whether or not a smoking history (≥10 pack-years) and emphysema are useful markers for classifying ACO and differentiating it from asthma with chronic airflow obstruction (CAO). Methods We retrospectively stud...

OBJECTIVES After completing this article, readers should be able to: 1. Identify the major environmental factors and comorbid conditions that affect asthma. 2. Describe the role of a written asthma action plan in the management of asthma. 3. Know how to assess asthma control and adjust therapy appropriately. 4. Discuss the evaluation and management of the child who has an acute exacerbation of ...

the prevalence of both obesity and asthma has increased in recent years. thus we decided to investigate the relation between obesity and asthma severity. we undertook a cross-sectional study in outpatient asthma clinics of 2 tertiary hospitals in tehran. obesity was defined as a body mass index greater than 30. asthma severity was defined by using the guide for asthma management and prevention ...

UNLABELLED The association between onset of asthma exacerbation and the inflammatory response has not been sufficiently studied. OBJECTIVE To determine the differential mechanisms of the rapid onset (RO) asthma exacerbation. METHODS We designed a prospective, multicentre study that included 34 patients who suffered from asthma exacerbation. They were distributed into three groups of asthmat...