A 40-year-old Japanese woman presented with slowly progressing parkinsonism in adulthood. She had a history of epilepsy with intellectual disability in childhood. In a head magnetic resonance scan, T2-weighted imaging showed low signal intensity areas in the globus pallidus and the substantia nigra; T1-weighted imaging showed a halo in the nigra. Because the patient's symptoms and history were ...

Diabetic retinopathy (DR) is a microvascular lesion that occurs as complication of diabetes mellitus. Many studies reveal retinal neurodegeneration early in its pathogenesis, and abnormal function can occur patients without any signs abnormalities. The gut microbiota large, diverse colony microorganisms colonize the human intestine. Studies indicated involved pathophysiological processes DR pla...

Age-dependent neurodegeneration is a pathological condition found in many metazoans. Despite the biological and medical significance of this condition, the cellular and molecular mechanisms underlying neurodegeneration are poorly understood. The availability of a large collection of mutants exhibiting neurodegeneration will provide a valuable resource to elucidate these mechanisms. We have deve...

OF DISSERTATION Radhika Anand Vaishnav The Graduate School University of Kentucky 2007 MOLECULAR MECHANISMS OF OLFACTORY NEURODEGENERATION _________________________________ ABSTRACT OF DISSERTATION _________________________________OF DISSERTATION _________________________________ A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Co...

Our previous studies have shown accumulation of GM2 ganglioside during ethanol-induced neurodegeneration in the developing brain, and GM2 elevation has also been reported in other brain injuries and neurodegenerative diseases. Using GM2/GD2 synthase KO mice lacking GM2/GD2 and downstream gangliosides, the current study explored the significance of GM2 elevation in WT mice. Immunohistochemical s...

In multiple sclerosis (MS), diffuse degenerative processes in the deep grey matter have been associated with clinical disabilities. We performed a systematic study in MS deep grey matter with a focus on the incidence and topographical distribution of lesions in relation to white matter and cortex in a total sample of 75 MS autopsy patients and 12 controls. In addition, detailed analyses of infl...

Contextual processing (or context processing; CP) is an integral component of cognition. CP allows people to manage their thoughts and actions by adjusting surroundings. involves the formation internal representation in relation environment, maintenance this information over a period time, updating mental representations reflect changes environment. Each these functions can be affected aging as...

abstract   introduction: neurodegeneration change is one of the hallmark symptoms of which alzheimer’s disease (ad) can be modeled by β-amyloid injection into specific regions of brain. (-)-epigallocatechin-3-gallate (egcg) is a potent antioxidant agent that its role against oxidative stress and inflammation has been shown in prior studies. in the present study, we have wanted to determine whet...