Several studies have now clearly indicated the presence of tumor-associated and tumor-specific antigens in cells of human malignant melanoma. These antigens have been identified by means of several quite different techniques, including the use of antibodies detectable against the antigens, either by means of immunofluorescence, (1-5) cytotoxicity (4, 6, 7) or by extracting the antigen and obtai...

1 Feusner JH, Slichter SJ, Harker LA. Mechanisms of thrombocytopenia in varicella. Am J Hematol 1979;7: 255-64. 2 Espinoza G, Kuhn C, Viral infection of megakaryocytes in varicella with purpura. Am J Clin Pathol 1974;61:203-8. 3 Winiarski J. IgG and IgM antibodies to platelet membrane glycoprotein antigens in acute childhood idiopathic thrombocytopenic purpura. BrJ Haematol 1989;73:88-92. 4 Win...

Glioblastoma (GBM)-initiating cells (GICs) are a tumorigenic subpopulation that are resistant to radio/chemotherapies and are the source of recurrence, therefore it is crucial to characterize GICs and find new therapeutic targets. We have successfully established mouse and human GICs, which retain stemness characteristics and tumorigenicity. By comparing their expression profiles with those of ...

Approved therapeutic antineoplastic antibodies have targeted extracellular or cell-surface molecules. ESK1 is the first fully human T-cell receptor-like antibody targeting an intracellular tumor-associated antigen, Wilm's tumor 1 (WT1). In murine xenograft models, ESK1 exhibits a high specificity and exert robust antineoplastic effects against human cancers that express WT1 epitopes on HLA-A201...

Since the first clear demonstration of the existence of 'specific' antigens in experimental tumours (Gross, 1943; Foley, 1953), the extensive use of syngeneic animals has resulted in the identification of tumour-associated or characteristic macromolecules ('antigens') in association with spontaneously occurring or experimentally induced tumours (Old and Boyse, 1964; Baldwin, 1970; Stonehill and...

Serologic studies using four murine monoclonal antibodies specific for the common acute lymphoblastic leukemia antigen (CALLA) and five monoclonal antibodies specific for the gp24 surface antigen indicate that these leukemia-associated antigens are present on cells of comparable tissues in man and in four nonhuman primates. As in man, adherent cell populations obtained from skin, lung, and bone...