BACKGROUND Aspirin is effective at reducing the cardiovascular event rate in defined patient groups. The introduction of antiplatelet therapies other than aspirin and the concept of aspirin resistance have led to critical reappraisal of current treatment. This review aims to clarify the evidence for aspirin resistance in patients with atherosclerosis. METHODS Medline search was performed to i...

BACKGROUND Aspirin resistance has been defined as inability of aspirin to protect individuals from thrombotic complications or to produce an anticipated effect from laboratory tests of platelet function. Most reported information comes from Western patients with coronary artery disease and aspirin resistance is defined by laboratory criteria. The purpose of the present study was to look for asp...

To assess the pharmacologic effects of aspirin on endogenous prostacyclin and thromboxane biosynthesis, 2,3-dinor-6-keto PGF1 alpha (PGI-M) and 2,3-dinor-thromboxane B2 (Tx-M) were measured in urine by mass spectrometry during continuing administration of aspirin. To define the relationship of aspirin intake to endogenous prostacyclin biosynthesis, sequential urines were initially collected in ...

OBJECTIVE To assess the prevalence of and related risk factors for aspirin resistance in elderly patients with coronary artery disease (CAD). METHODS Two hundred and forty-six elderly patients (75.9 ± 7.4 years) with CAD who received daily aspirin therapy (≥ 75 mg) over one month were recruited. The effect of aspirin was assessed using light transmission aggregometry (LTA) and thrombelastogra...

Numerous studies have evaluated the efficacy and safety of low dose aspirin for preeclampsia prevention in high risk women. Most were European based demonstrating with 150 mg, United States supporting 81 mg prevention. There is limited data from evaluating 162 mg; aim this study was to examine vs no A retrospective cohort performed at Henry Ford Health System (HFHS) between 2013 2020. The ‘no a...

Latar belakang: Ulkus peptikum merupakan kerusakan lapisan mukosa biasanya di lambung atau duodenum. Aspirin obat dari golongan NSAIDs yang menjadi penyebab ulkus peptikum. Madu memiliki aktivitas antioksidan senyawa terkandung dalam madu berupa flavonoid dan asam fenolat. Noor et al membuktikan bahwa dapat melindungi tubuh efek toksik bahan kimia. Tujuan: Mengetahui protektif pada jaringan duo...

In most studies, aspirin has been shown to be effective for a period of 1 year in reducing the frequency of saphenous vein bypass graft occlusion when begun 1 day before surgery, on the day of surgery, or the day after surgery. Effective doses of aspirin range from 100 to 975 mg/d. Aspirin in combination with dipyridamole is effective in the prevention of saphenous vein bypass graft occlusion i...

INTRODUCTION The use of aspirin in patients without cardiovascular disease remains controversial. Patients' understanding of the risks and benefits of aspirin likely contribute to the decision of whether or not to use aspirin regularly. The purpose of this study is to assess patients' knowledge of aspirin and identify factors contributing to regular use. METHODS A survey of U.S. adults aged 4...

OBJECTIVE Aspirin blocks thromboxane production that contributes to its well-appreciated antiplatelet action. Aspirin also initiates the biosynthesis of novel antiinflammatory mediators from arachidonic acid, namely aspirin-triggered 15-epi-lipoxin A4. We recently conducted a double-blinded clinical trial with healthy subjects in whom low-dose aspirin (81 mg daily) significantly increased aspir...

OBJECTIVE To provide an evidence-based focused review of aspirin use in the perioperative period along with an in-depth discussion of the considerations and risks associated with its preoperative withdrawal. BACKGROUND For patients with established cardiovascular disease, taking aspirin is considered a critical therapy. The cessation of aspirin can cause a platelet rebound phenomenon and prot...