The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infecti...

Invasive pulmonary aspergillosis is most commonly seen in immunocompromised patients. Besides, skin lesions may also develop due to invasive aspergillosis in those patients. A 49-year-old male patient was diagnosed with acute myeloid leukemia. The patient developed bullous and zosteriform lesions on the skin after the 21st day of hospitalization. The skin biopsy showed hyphae. Disseminated skin...

Human central nervous system (CNS) aspergillosis has >90% mortality. We compared posaconazole with other antifungals for efficacy against murine CNS aspergillosis. All tested regimens of posaconazole were equivalent to those of amphotericin B and superior in prolonging survival and reducing CFU to those of itraconazole and caspofungin and to vehicle controls. No antifungal regimen effected cure...

INTRODUCTION Pulmonary aspergillosis has variable course of illness, severity and outcomes depending on underlying conditions. There is limited data available on the clinical manifestations and outcome of pulmonary aspergillosis from Pakistan. METHODS To determine the clinical manifestations and outcome of pulmonary aspergillosis in a tertiary care hospital a retrospective study was conducted...

background and purpose: chronic granulomatous disease (cgd) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (nadph) oxidase complex. this disorder results in recurrent life-threatening bacterial and fungal infections. aspergillus species are the most common fungal infections in these patients. case report: herein, we present a case of fungal infection in a girl with ...

background invasive aspergillosis is a major cause of morbidity and mortality in immunosuppressed patients. thisn infection is caused by aspergillus, a hyaline mold, which is the etiologic agent for many different manifestations. patient a 63 year old diabetic housewife woman, living in northern iran, presented with the history of right eye ptosis after a mild head trauma since about 3 weeks ag...

Nosocomial invasive aspergillosis can cause life-threatening infections among immunosuppressed patients and is thought to be primarily airborne. Despite the use of appropriate hospital air filtration systems, however, the incidence of this infection continues to increase. In this article, we present our hypothesis, which is that nosocomial aspergillosis can be airborne from a water source in th...

Invasive aspergillosis is a life-threatening fungal infection, especially in immunocompromised patients. Pulmonary aspergillosis is the most common type of the infection, while urinary tract infection is relatively rare. Here, we describe a case of a 46-year-old man with chronic renal disease presenting with intermittent abdominal pain. The diagnosis of aspergillosis was established by patholog...

We describe a patient with rapidly progressive pneumonia and a high level of serum lactate dehydrogenase, in whom postmortem study revealed the presence of a diffuse, small and large-cell multicentric non-Hodgkin's lymphoma, together with an invasive pulmonary aspergillosis. Aspergillosis is rare as a presenting feature of a lymphoproliferative disease; only one previous case has been reported ...