The effects of large doses of L-phenylalanine and of aspartame on seizure susceptibility and severity have been assessed in baboons Papio papio from Senegal which show photosensitive epileptic responses similar to primary generalised epilepsy in man. L-Phenylalanine, 50, 150 or 450 mg/kg, or aspartame, 300 or 1000 mg/kg, were administered orally. Peak plasma L-phenylalanine concentrations of ap...

Advantame is a new ultrahigh-intensity noncaloric sweetener derived from aspartame and approved for human use. Rats and mice are not attracted to the taste of aspartame and this study determined their preference for advantame. In 24-h choice tests with water, C57BL/6J mice and Sprague-Dawley rats were indifferent to advantame at concentrations of 0.01, 0.03, and 0.1mM but significantly preferre...

Introduction: Aspartame (ASP) is the most widely used artificial sweeteners entering in the component of many foods and beverages. There was a great matter of controversy about the effect of aspartame on body cells. Aim of the Work: Was to evaluate the effect of aspartame on the structure the cerebellar cortex in rats. Materials and Methods: Fifteen male adult albino rats were used. The animals...

Aspartame is an intense sweetener which is increasingly used in the UK. It is registered at an acceptable daily intake (ADI) of 40 mg/kg, although there are no previous data relating to the metabolism of aspartame in older people. Twelve young and 12 elderly volunteers each received a single dose of approximately 40 mg/kg of aspartame. Baseline concentrations of phenylalanine (the main metaboli...

Aspartame is an intense sweetener which is increasingly used in the UK. It is registered at an acceptable daily intake (ADI) of 40mg/kg, although there are no previous data relating to the metabolism of aspartame in older people. Twelve young and 12 elderly volunteers each received a single dose of approximately 40mg/kg of aspartame. Baseline concentrations of phenylalanine (the main metabolite...

Aspartame is widely consumed by humans who are diabetic and who are under weight loss regime. Aspartame (L-aspartyl-L-phenylalanine methyl ester) also known as NutraSweet, after oral administration to humans and experimental animals, aspartame is rapidly and completely metabolized to 50% phenylalanine, 40% aspartic acid and 10% methanol[1]. Methanol is being increasingly recognized as a substan...