نتایج جستجو برای: asian continental ancestry group
تعداد نتایج: 1066264 فیلتر نتایج به سال:
The United States has experienced rapid growth of the Asian American population in the last decade. People of mixed ancestry are a significant proportion of Asian America. Little is known about the health beliefs and health practices of this extremely diverse population. Thirteen older racially mixed Asian Americans, ranging in age from 48-94, were interviewed in a qualitative study that includ...
CONTEXT Information on the prevalence of pathogenic BRCA1 mutation carriers in racial/ethnic minority populations is limited. OBJECTIVE To estimate BRCA1 carrier prevalence in Hispanic, African American, and Asian American female breast cancer patients compared with non-Hispanic white patients with and without Ashkenazi Jewish ancestry. DESIGN, SETTING, AND PARTICIPANTS We estimated race/et...
AIMS Genome-wide association studies highlighted single nucleotide polymorphisms (SNPs) within the IFNL3/IL28B locus predict the treatment outcome for patients with HCV. Furthermore, SNPs in newly discovered IFNL4 are shown to have population-specific correlation with spontaneous clearance of HCV. The aim of this study was to examine the prevalence and clinical significance of the outlined SNPs...
This document is an update to the 2011 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin dosing. Evidence from the published literature is presented for CYP2C9, VKORC1, CYP4F2, and rs12777823 genotype-guided warfarin dosing to achieve a target international normalized ratio of 2-3 when clinical genotype results are available. In ad...
The last decade has witnessed important advances in our understanding of the genetics of pigmentation in European populations, but very little is known about the genes involved in skin pigmentation variation in East Asian populations. Here, we present the results of a study evaluating the association of 10 Single Nucleotide Polymorphisms (SNPs) located within 5 pigmentation candidate genes (OCA...
The majority of GWAS of T2D susceptibility have been undertaken in populations of European ancestry1–5, predominantly because of existing infrastructure, sample availability and relatively poor coverage by many of the earliest genome-wide genotyping arrays of common genetic variation in other major ethnic groups6. However, populations of European ancestry constitute only a subset of human genet...
The incidence rate of hepatocellular carcinoma (HCC) is higher in populations of Asian ancestry than European ancestry (EA). We sought to investigate HCC mutational differences between the two populations, which may reflect differences in the prevalence of etiological factors. We compared HCC somatic mutations in patients of self-reported Asian American and EA from The Cancer Genome Atlas (TCGA...
While South Americans are underrepresented in human genomic diversity studies, Brazil has been a classical model for population genetics studies on admixture. We present the results of the EPIGEN Brazil Initiative, the most comprehensive up-to-date genomic analysis of any Latin-American population. A population-based genome-wide analysis of 6,487 individuals was performed in the context of worl...
Genomic studies have shown thatNeanderthals interbredwithmodern humans,andthatnon-Africanstodayare theproductsof thismixture. The antiquity ofNeanderthal gene flow intomodernhumansmeans thatgenomic regions thatderive fromNeanderthals inanyonehuman todayareusually less thanahundredkilobases in size.However,Neanderthal haplotypes are also distinctive enough that several studies have been able to ...
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