Ca participates in the stimulation of hepatic gluconeogenesis by glucagon and there is evidence that Ca fluxes are modified in arthritic rats. These findings raise the question whether hepatic gluconeogenesis in arthritic rats responds differently to glucagon and Ca. The experimental system was the isolated perfused rat liver. In the presence of Ca, stimulation of hepatic gluconeogenesis by glu...

BACKGROUND Neoangiogenesis occurring in inflamed articular synovium in early rheumatoid arthritis (RA) is characterized by enhanced vascular permeability that allows nanoparticle agents, including liposomes, to deliver encapsulated drugs to arthritic joints and subsequently improve therapeutic efficacy and reduce adverse effects. However, the targeting distribution of liposomes in arthritic joi...

INTRODUCTION We previously demonstrated that a single-chain fragment variable (scFv) specific to collagen type II (CII) posttranslationally modified by reactive oxygen species (ROS) can be used to target anti-inflammatory therapeutics specifically to inflamed arthritic joints. The objective of the present study was to demonstrate the superior efficacy of anti-inflammatory cytokines when targete...

The present study is aimed to evaluate the anti-arthritic activity of novel Schiff bases of cinnamldehyde using in-vitro inhibition of protein denaturation model. All the compounds synthesized were characterized by running TLC, UV, IR & MS spectra. Diclofenac sodium was used as a standard drug for anti-arthritic activity. Results revealed that the derivative Cinnan 2 possessed significant anti-...

The main objective of the present work is to evaluate potential Lantana camara (aculeata) for anti-arthritic activity using in vitro and vivo study. L. an important medicinal, ornamental, essential oil-producing herb from family Verbenaceae. Different parts have been used treatment various human ailments such as itches, cuts, ulcers, swellings, bilious fever, eczema, tetanus, malaria, tumor, rh...

OBJECTIVE The contribution of local VEGF production and subsequent angiogenesis within the synovial membrane to the propagation of arthritis is unclear. The relationship between synovial oxygenation and blood flow in the development of arthritic disease is unknown. We have therefore measured oxygen levels and perfusion rates in the synovial space in a murine model of arthritis. METHODS Arthri...