background diabetes mellitus is a widespread disease. its vascular complications can be characterized by arteriosclerosis formation in carotid arteries. due to its delayed diagnosis resulting in more complications in iran, it seems that screening diabetic patients is mandatory. objectives the aim of this study was to compare the intima-media thickness (imt) of carotid artery in diabetic and non...

• Considerable emphasis is given to the investigation of the coronary and cerebral arteries because of the dramatic consequences of arteriosclerosis in these vessels. It is well known that the severity of arterial disease differs from one anatomical site to another. Hence greater emphasis should be placed on understanding the anatomical distribution of arteriosclerosis, particularly since recov...

OBJECTIVES Transplant arteriosclerosis is a major obstacle for long-term allograft survival in heart transplant. The aim of this study was to investigate potential synergistic effects of combined treatment with mycophenolate mofetil and ganciclovir on the development of transplant arteriosclerosis, presence of regulatory T cells, and expression of donor specific alloantibodies. MATERIALS AND ...

Amlodipine (a new class of calcium channel antagonist) has been shown to limit the progression of arteriosclerosis and decrease the incidence of cardiovascular events. The mechanisms underlying the beneficial effects of amlodipine, however, remain unclear. Therefore, we hypothesized that amlodipine attenuates the development of arteriosclerosis through the inhibition of inflammation in vivo. Lo...

A tortuous common carotid artery poses a high risk of injury during tracheotomy. Preoperative diagnosis is therefore important to avoid serious complications. We found four cases of tortuous common carotid artery during an anatomical dissection course for students. The first case was a 91-year-old woman who had bilateral tortuous common carotid arteries without arteriosclerosis. Case 2 was a 78...

BACKGROUND It remains unclear whether vascular endothelial growth factor (VEGF) is a proarteriosclerotic or an antiarteriosclerotic factor. We recently reported that long-term inhibition of nitric oxide by administering Nomega-nitro-L-arginine methyl ester (L-NAME) induces coronary vascular inflammation and arteriosclerosis. METHODS AND RESULTS We used this animal model to investigate the rol...

Atherosclerosis represents a spectrum of pathologic lesions with diverse clinical sequelae. In this review, we build upon the paradigm that arteriosclerosis represents an inflammatory disease. By examining mechanisms involved in the response to vascular injury, we can more effectively implement targeted therapy aimed at halting or regressing arteriosclerosis.