Abstract: Aim: Breast cancer is one of the most common cancers among women, consistently elevated estrogen level in blood associated with persistently breast found many studies. The mechanisms carcinogenesis whereby involved conversion androgen to presence enzyme aromatase. Materials and Methods: Aromatase a (CYP19), cytochrome P450, which that synthesizes estrogen. expressed higher concentrati...

Background Estrogens biosynthesis in ejaculated spermatozoa is an autonomous process that may influence sperm functions. The purpose of this study was to evaluate the relationship between the expression of aromatase, sperm quality and seminal neutral α–glucosidase marker in semen of Tunisian infertile men. MaterialsAndMethods Fifty seven men were investigated: they were composed of two groups: ...

A quantitative structure-activity relationship (QSAR) approach by use of the minimal topological difference (MTD) method including 46 derivatives of 4-androstene-3,17-dione and 5 alpha-androstane-3,17-dione is applied to give indications about the role of the C4 = C5 double bond in competitive inhibition of human placental aromatase and about sterical requirements in steroid-aromatase interacti...

OBJECTIVE To investigate the effect of peroxisome proliferator activated receptor γ (PPARγ) agonist on the cell proliferation properties and expression of human telomerase reverse transcriptase (hTERT) and aromatase in cultured endometrial stromal cell (ESC) from patients with endometriosis. METHODS Human endometrial tissues were obtained from women with endometriosis and healthy women (contr...

To study the role of extracellular nucleosides and nucleotides in the regulation of Sertoli cells, the effects of agonists which occupy A1 and P2 purinergic receptors on aromatase and gamma-glutamyl transpeptidase (gamma-GTP) activities and on transferrin secretion were tested. Sertoli cell treatment with purinergic agonists for a prolonged period of time (72 h) resulted in an increase in aroma...

the object of the present study was to establish conditions (optimal serum concentration and growth factor supplement) for prolonged culture of pig granulosa cells (gc). gc were cultured in the presence of different fetal calf serum (fcs) concentrations (10% and 20%) and one of the following growth factors: leukemia inhibitory factor (lif), basic fibroblast growth factor (bfgf) and stem cell fa...