Monitoring of the interface temperature at skin level in lower-limb prosthesis is notoriously complicated. This is due to the flexible nature of the interface liners used impeding the required consistent positioning of the temperature sensors during donning and doffing. Predicting the in-socket residual limb temperature by monitoring the temperature between socket and liner rather than skin and...

Background: Several large randomised controlled trials (RCTs) in primary Sjögren’s syndrome (pSS) failed to demonstrate drug efficacy. 1-4 Many of these used ESSDAI as endpoint, showing but similar response rates active treatment and placebo groups. 1,3,4 Given the heterogeneous nature pSS, there is need for a composite endpoint including multiple clinically relevant parameters. Objectives: To ...

Thromb Haemost 2009; 101: 997–998 The contributions encapsulated in this themed issue of Thrombosis and Haemostasis derive from invited lectures at the 15th International Vascular Biology Meeting (IVBM) held in June, 2008 in Sydney, Australia. IVBMs, which are held every two years, have become the most prestigious international biomedical conference in blood vessel biology and disease. The scie...

Various studies indicate that the hippocampus plays an essential role in novelty detection. In particular, contextual/spatial changes are detected by the hippocampus, presumably by comparing incoming information with stored information (e.g., Knight, 1996). However, the exact nature and processes underlying hippocampal novelty detection remain elusive. One important mechanism that may underlie ...

Schwindt et al., raise concerns about a passage in the algorithm of latest European Resuscitation Council (ERC) newborn life support (NLS) guidance. The authors are worried that ERC-NLS recommendation to “Consider intubation if not done already (or laryngeal mask possible)” may be interpreted as an imperative intubate when commencing chest compressions (CC). They speculate this would delay deli...

Despite extensive research during the last decades, coronary artery disease (CAD) remains the number one cause of death, responsible for near 50% of global mortality. A main reason for this is that CAD has a complex inheritance and etiology that unlike rare single gene disorders cannot fully be understood from studies of of genes one-by-one.In parallel, studies that simultaneously assess multip...

Background Today, there are still no DMARDs licensed for primary Sjögren Syndrome (pSS) patients. Among the explanations, limitations of current outcome measures used as endpoints: e.g; high placebo response rate, evaluation either symptoms or systemic activity, and important features not being assessed. The NECESSITY consortium ( https://www.necessity-h2020.eu/ ), including pSS experts from ac...

Introduction Nowadays, the unemployment crisis has had irreparable effects as a fundamental problem on all the economic, social and cultural aspects of the community. So that the stability and destruction of some governments depends on solving the unemployment crisis. The issue of economic development has always been one of the main concerns of countries. There are two factors that affect deve...

Class Derived Class Provides the Interface Fig. 4. The separation between interface and implementation PRORISC/IEEE WORKSHOP, MIERLO NOV. 27-28 1997, THE NETHERLANDS 5 Therefore, we have de ned an abstract class Bu er that provides the method read and write. From the abstract class, we derived new classes, that implement a speci c behavior as shown in gure 4. In case of the handshake bu er we i...