BACKGROUND One of the primary obstacles to the widespread adoption of openEHR methodology is the lack of practical persistence solutions for future-proof electronic health record (EHR) systems as described by the openEHR specifications. This paper presents an archetype relational mapping (ARM) persistence solution for the archetype-based EHR systems to support healthcare delivery in the clinica...

Rearrangements of the JC virus (JCV) regulatory region (RR) are consistently found in the brains of patients with progressive multifocal leukoencephalopathy (PML), whereas the archetype RR is present in their kidneys. In addition, the C terminus of the large T antigen (T-Ag) shows greater variability in PML than does the rest of the coding region. To determine whether similar changes in simian ...

Benthic infaunal species and communities have been extensively used to evaluate quality of the marine environment. Within the MSFD, community composition is addressed most commonly through Descriptor 6 (Seafloor integrity), criterion 6.2 (Condition of benthic communities). At the same time, the Directive has stipulations for addressing and assessing indicators linked with pressures in an explic...

INTRODUCTION This article is part of the Focus Theme of METHODS of Information in Medicine on "Managing Interoperability and Complexity in Health Systems". BACKGROUND The proliferation of archetypes as a means to represent information of Electronic Health Records has raised the need of binding terminological codes - such as SNOMED CT codes - to their elements, in order to identify them univoc...

BACKGROUND Clinical data registry is designed to collect and manage information about the practices and outcomes of a patient population for improving the quality and safety of care and facilitating novel researches. Semantic interoperability is a challenge when integrating the data from more than one clinical data registry. The openEHR approach can represent the information and knowledge seman...

Clinical decision support systems can be improved if data exchange among different organizations with full and understandable clinical meaning is achieved. Towards this end, the development of new methodologies of information management is necessary. Among them, CEN/ISO EN13606 (archetypes) is the most promising approach. According to World Health Organization, cardiovascular diseases are the l...

Studies have indicated that national culture may impact the choice of who shares knowledge with whom. This paper considers the problem of tacit knowledge sharing in multi-cultural environments and the issues that relate to trust, language, and culture that could impact on tacit knowledge sharing choices. A study was conducted in an international and multi-cultural Business School to discover if...