Aim: In this study we researched the effect of chronic hepatitis C virus (HCV) infection on serum lipid profile. Method: 28 patients (age average: 58.2±7.9 years) 17 of them women and 11 of them men and 33 healthy people (age average: 51.1±7.4 years) 22 of them women and 11 of them men taking chronic hepatitis C diagnosis through liver biopsy and in that any treatment wasn’t started yet were ta...

To measure apolipoprotein A-I, we use an RIA kit (Ventrex Laboratories, Inc., Portland, ME) for which serum is recommended, and avoidance of repeated freeze-thaw cycles. With the reported association of alterations in apolipoprotein A-I concentrations in plasma with both heart (1) and liver disease (2), those interested in retrospectively measuring apolipoprotein A-I with this kit have been lim...

Article type: Original article Background & aim: This study aimed to determine the relationship between lipid and apolipoprotein B-100 (apo B-100) levels in maternal and umbilical cord sera as well as the effects of these components on anthropometric measurements of newborn infants. Methods: This correlational study was performed on 85 appropriate for gestational age (AGA) newborns and their mo...

Apolipoproteins C-I1 (apoC-11) and C-111 (apoC-111) are distributed among all the major lipoprotein classes, particularly very low density (VLDL) and high density lipoproteins (HDL). We have determined concentrations of apoC-I1 and apoC-111 in VLDL and HDL in subjects with a wide range of VLDL triglyceride and HDL cholesterol levels, and correlated these levels with fractional catabolic rates (...

Accumulating evidence suggests that cellular lipoprotein components are involved in hepatitis C virus (HCV) morphogenesis, but the precise contribution of these components remains unclear. We investigated the involvement of apolipoprotein C1 (ApoC1) in HCV infection in the HCV pseudotyped particle system (HCVpp), in the recently developed cell culture infection model (HCVcc), and in authentic H...

Background/Aims Changes in lipid profiles in patients infected with hepatitis C virus (HCV) during direct-acting antiviral therapy have been reported in recent years. However, the clinical aspects of disturbed lipid metabolism in chronic HCV infection have not been fully elucidated. Methods Dynamic changes in serum total, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) chole...

Like rat C apolipoproteins, each of the C apolipoproteins from human blood plasma (C-I, C-II, C-III-1, and C-III-2) bound to small chylomicrons from mesenteric lymph of estradiol-treated rats and inhibited their uptake by the isolated perfused rat liver. This inhibitory effect of the C apolipoproteins was independent of apolipoprotein E, which is present only in trace amounts in these chylomicr...

This review assesses current knowledge of the clinical, genetic, and biochemical features of familial high density lipoprotein (HDL) deficiency syndromes. The focus is on HDL deficiency states occurring in the absence of severe hypertriglyceridemia or lecithin/cholesterol acyltransferase deficiency. Specific entities falling within this category include Tangier disease, familial HDL deficiency ...