CONTENTS Summary of key points and recommendations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1256 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1257 Capsaicin and citric acid inhalation cough challenge . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1258 Cough induced by ...

BACKGROUND Cough variant asthma (CVA) is a phenotype of asthma presenting solely with coughing, characterized by airway hyperresponsiveness, eosinophilic inflammation and a cough response to bronchodilators. Leukotriene receptor antagonists (LTRAs) are antiasthma medications with anti-inflammatory and bronchodilatory properties. Although LTRAs exert antitussive effects in CVA, the mechanisms in...

Transient receptor potential vanilloid 1 (TRPV1) plays an integral role in modulating the cough reflex, and it is an attractive antitussive drug target. The purpose of this study was to characterize a TRPV1 antagonist, 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), against the guinea pig TRPV1 receptor in vitro followed by a...

Cough is a common symptom of respiratory diseases associated with irritation or inflammation of the airways, and symptomatic antitussive drugs are frequently prescribed to control an abnormal cough reflex. Our aim was to evaluate the effects of moguisteine, a novel, peripheral, nonnarcotic antitussive agent, on airway inflammation induced in guinea-pigs with a variety of stimuli. These stimuli ...

background: the relaxant and anticholinergic (functional antagonism) effects, histamine h 1 inhibitory effect, and calcium channel blocking effect of nigella sativa have been demonstrated on guinea pig tracheal chains.  several therapeutic effects including anti-asthma and dyspnea have also been ascribed to the seeds of nigella sativa.   objective: to evaluate the antitussive effect of this pla...

The roots of Stemona tuberosa have been used as an antitussive and insecticide remedy for thousands of years. On the chemical investigation of the roots of S. tuberosa, two new tuberostemonine-type alkaloids, epoxy-tuberostemonol (1), and neotuberostemoenone (2), together with a known alkaloid, neotuberostemonine, were isolated and identified. The structures of new alkaloids were established on...

BACKGROUND gamma-Aminobutyric acid (GABA) is a central inhibitory neurotransmitter that also exists in peripheral tissues, including the lung. The GABA-agonist baclofen has been shown, in animal studies, to inhibit cough via a central mechanism, but has not been investigated in humans (to our knowledge). STUDY OBJECTIVE To evaluate the antitussive effect of baclofen in normal human subjects. ...