background: the most important limitation of glass ionomer cements (gics) is the weak mechanical properties. our previous research showed that higher mechanical properties could be achieved by addition of forsterite (mg2sio4) nanoparticles to ceramic part of gic. the objective of the present study was to fabricate a glass ionomer- mg2sio4 nanocomposite and to evaluate the effect of addition of ...

background: dental cobalt base alloys are biocompatible dental materials and have been widely used in dentistry. however, metals are bioinert and may not present bioactivity in human body. bioactivity is the especial ability to interact with human body and make a bonding to soft and hard tissues. the aim of the present research was fabrication and bioactivity evaluation of novel cobalt alloy/ f...

Objectives. To evaluate methotrexate effect on tumor necrosis factor (TNF) alpha bioactivity during infliximab (IFX) therapy in rheumatoid arthritis (RA) patients and to correlate TNF bioactivity with antibody towards IFX (ATI) development and RA clinical response. Materials and Methods. Thirty-nine active women RA patients despite conventional synthetic disease modifying antirheumatic drugs (c...

The starfish SALMFamide neuropeptides S1 (GFNSALMFamide) and S2 (SGPYSFNSGLTFamide) are the prototypical members of a family of neuropeptides that act as muscle relaxants in echinoderms. Comparison of the bioactivity of S1 and S2 as muscle relaxants has revealed that S2 is ten times more potent than S1. Here we investigated a structural basis for this difference in potency by comparing the bioa...

The value of measuring IGF1 bioactivity in active acromegaly is unknown. Soluble Klotho (S-Klotho) level is elevated in active acromegaly and it has been suggested that S-Klotho can inhibit activation of the IGF1 receptor (IGF1R). A cross-sectional study was carried out in 15 patients with active acromegaly based on clinical presentation, unsuppressed GH during an oral glucose tolerance test, a...

MOTIVATION Certain chemical substructures are present in many drugs. This has led to the claim of 'privileged' substructures which are predisposed to bioactivity. Because bias in screening library construction could explain this phenomenon, the existence of privilege has been controversial. RESULTS Using diverse phenotypic assays, we defined bioactivity for multiple compound libraries. Many s...

Epithelial Ovarian cancer is the leading cause of cancer mortality among women all over the world. As chemotherapeutics has many side effects, researchers have focused on the potential use of medicinal plants as natural antitumor agents. Xanthium strumarium studied in this work as an herbal anticancer agent. This study aimed to evaluate the antitumor effect and metabolic alterations ca...

Silicates are well known for their bioactivity, here we are reporting the bioactivity of diopside (CaMgSi2O6) synthesized by sol-gel combustion process by using citric acid and succinic acid as a mixed fuel. The phase formation of the prepared sample was confirmed by powder X-Ray Diffraction. In-vitro bioactivity of the diopside in conjugation with biopolymer chitin in various proportions were ...

Assessment of biological potency and its comparison with clinical effects are important in the quality control of therapeutic glycoproteins. Animal models are usually used for evaluating bioactivity of these compounds. However, alternative methods are required to simplify the bioassay and avoid ethical issues associated with animal studies. Negatively charged sialic acid residues are known to b...