Antipsychotics (APs) are psychotropic drugs that generally have a psycholeptic effect, capable of reducing psychotic symptoms and psychomotor agitation. This class is widely used in psychiatric practice, especially for the treatment psychosis schizophrenia other disorders. Most APs pass through biotransformation process, or metabolism, after they enter body before being eliminated. There three ...

OBJECTIVES To investigate the association between use of typical and atypical antipsychotic drugs and incidence of stroke in patients with and without dementia. DESIGN Self controlled case series. SETTING UK based electronic primary care records in the general practice research database (GPRD). PARTICIPANTS All patients registered in the database with a recorded incident stroke and at lea...

OBJECTIVE To identify factors associated with incident cardiovascular events and metabolic disturbance in children and adolescents treated with antipsychotics. DESIGN A retrospective cohort design evaluating Medicaid medical and pharmacy claims. SETTING South Carolina's Medicaid program covering outpatient and inpatient medical services and medication prescriptions from January 1, 1996, thr...

Switching antipsychotics is common in the clinical practice setting and is associated with potential clinically relevant complications. An expert group selected by Spanish Society of Psychiatry and the Spanish Society of Biological Psychiatry has reviewed the evidence provided by randomized clinical trials and other relevant information to reach consensus recommendations for switching antipsych...

BACKGROUND Conventional and atypical antipsychotic medications are approved by the FDA for treatment of schizophrenia and bipolar disorder. Over many decades, the widespread use of conventional antipsychotics produced various side effects requiring additional medications, such as the atypical antipsychotics. Beginning in 2006, 9 atypical antipsychotic drugs have been approved by the FDA for ind...

BACKGROUND Previous meta-analyses of atypical antipsychotics for depression were limited by few trials with direct comparisons between two treatments. We performed a network meta-analysis, which integrates direct and indirect evidence from randomized controlled trials (RCTs), to investigate the comparative efficacy and tolerability of adjunctive atypical antipsychotics for treatment-resistant d...