The aim of this work was to determine if the inhibition or stimulation of NO synthesis modulates liver damage induced by chronic lead intoxication. Lead nitrate (3.6 mg/kg, per os) was administered one time a day for 30 days to male Wistar rats with low and high resistance to hypoxia treated simultaneously with L-arginine (600 mg/kg, i.p.) or N-nitro-L-arginine (L-NNA, 35 mg/kg, i.p.) 30 min. b...

the etiopathogenesis of alzheimer's disease (ad) is still unclear.  however, long-term oxidative stress is believed to be one of the major contributing factors in progression of neuronal degeneration and decline of cognitive function in ad. in order to assess the presence of oxidative stress in ad, we examined the enzymatic activities of the erythrocyte cu-zn superoxide dismutase (cu-zn sod), g...

Oxidative stress has been widely implicated in both hypertension and chronic kidney disease (CKD). Hypertension is a major risk factor for CKD progression. In the present study we have investigated the effects of chronic single tempol (membrane-permeable radical scavenger) or losartan (angiotensin II type 1 receptor blocker) treatment, and their combination on systemic oxidative status (plasma ...

Patients with chronic kidney disease (CKD) have high cardiovascular mortality and morbidity and a high risk for developing malignancy. Excessive oxidative stress is thought to play a major role in elevating these risks by increasing oxidative nucleic acid damage. Oxidative stress results from an imbalance between reactive oxygen/nitrogen species (RONS) production and antioxidant defense mechani...

objective oxygen intoxication plays an important role in the pathogenesis of some fetal diseases such as encephalopathy, ischemia& hypoxia. antioxidants can reduce oxidative damage in newborns. the object of this research was measuring total value of antioxidant and vitamin c in blood sample of pregnant women before delivery, and also in umbilical cord blood of their newborn, and repeating thes...

*Correspondence: Bojjam V. Vardhini, Department of Botany, Telangana University, Dichpally, Nizamabad 503322, India e-mail: drvidyavardhini@ rediffmail.com Various abiotic stress factors significantly contribute to major worldwide-losses in crop productivity by mainly impacting plant’s stress tolerance/adaptive capacity. The latter is largely governed by the efficiency of antioxidant defense sy...

Abstract: Present study evaluated the anti-clastogenic efficacy of Azadirchta indica (A. indica) against benzo(a)pyrene [B(a)P] in murine forestomach tumorigenesis bioassay protocol. Female Balb/c mice were divided into four groups (n = 8). Each mouse from B(a)P and B(a)P + A. indica groups received intragastric instillations of B(a)P at a dose of 40 mg/kg b. w. in 0.2 mL olive oil twice a week...

Physiological processes, as aerobic metabolism and inflammatory response, generate reactive oxygen species (ROS) that may induce cellular injury when their amount is increased and antioxidant defense mechanisms are overwhelmed. Also, ROS are generated following UV skin irradiation able to deplete the natural antioxidant defenses in the skin. The increase in exposure to UV may lead to photoaging...