The genetic background of systemic lupus erythematosus (SLE) has been reexamined in a study of the serum of 31 lupus patients and 80 asymptomatic first degree relatives by measuring a common, cross reacting anti-DNA antibody idiotype designated 134, antibodies to poly(ADP-ribose), serum C3, circulating immune complexes, and antinuclear antibodies (ANA). Over 30% of the relatives had raised 134 ...

Antithyroid antibodies (Abs) are associated with epilepsy in steroid-responsive encephalopathy, but have been rarely studied in unselected epilepsy patients. This study aimed to characterize the prevalence and associated factors of antithyroid Abs and other auto-Abs in adult patients with epilepsy.Epilepsy patients without autoimmune disorders were surveyed for antinuclear antibody (ANA), anti-...

Linear morphea in an en coup de sabre pattern is a variant of localized scleroderma that develops on the frontal or frontoparietal scalp. Approximately two-thirds of cases occur before the age of 18. The etiology is unknown, but the disease is thought to be most likely autoimmune in nature. Between 50% and 75% of these patients have been found to have a positive serum antinuclear antibody (ANA)...

ANA = antinuclear antibody; AS = ankylosing spondylitis; ATTRACT = Anti-TNF Trial in Rheumatoid Arthritis with Comcomitant Therapy; BASDAI = Bath Ankylosing Spondylitis Disease Activity Index; BASFI = Bath Ankylosing Spondylitis Functional Index; BASGI = Bath Ankylosing Spondylitis Disease Global Index; BASMI = Bath Ankylosing Spondylitis Metrology Index; DMARD = disease-modifying antirheumatic...

In a population based epidemiological survey of juvenile chronic arthritis (JCA), performed in Western Sweden in 1983, an incidence of 12/100,000 was found. The estimated prevalence was 56/100,000. Subgroup distribution showed a preponderance of mono- and pauciarticular forms. The peak age of onset was between 0 and 4 years of age. Girls predominated over boys in a ratio of 3:2. Overall, 30% we...

OBJECTIVE In 2013, the American College of Rheumatology (ACR) participated in the Choosing Wisely campaign and devised a recommendation to avoid testing antinuclear antibody (ANA) subserologies without a positive ANA and clinical suspicion of disease. The goals of our study were to describe ANA and subserology ordering practices and predictors of ordering concurrent ANA and subserologies in a s...

Methods We reported a newborn infant with macrophage activation syndrome (MAS) born from a mother with positive antinuclear (ANA) and anti-SSA/Ro antibodies. The 2,500 g girl was born at 37 weeks of gestation in good condition. Mother had been diagnosed with adult onset Still disease 10 years previously. During pregnancy, she did not take any medication as she was free of symptoms. The baby was...

Acquired von Willebrand’s syndrome (AvWS) is a rare heterogeneous bleeding disorder that could be secondary to many underlying diseases, among which systemic lupus erythematosus (SLE) is a less common cause. We presented an uncommon juvenile-onset SLE with AvWS as the first manifestation, whose autoantibodies were all negative except for low-titer positive antinuclear antibody (ANA). Initial co...

Background: The aim of this study was to determine the reasons for request antinuclear antibody (ANA) in ANA-positive patients and final diagnosis these whether they developed a rheumatologic disease. Method: In retrospective study, files 559 with positive ANA were reviewed. Demographic, laboratory clinical characteristics noted. At end follow-up, recorded. Results: included 346 patients. 233 f...

INTRODUCTION The non-histone nuclear protein high mobility group box protein-1 (HMGB1) is typically associated with nucleosomes, but may shuttle between the nucleus and the cytoplasm, and under some conditions also be released extracellularly and participate in systemic inflammation. Monoclonal HMGB1-targeting antibodies can ameliorate murine polyarthritis and lupus-like disease. Interestingly,...