OBJECTIVES Persistent contamination of surfaces by spores of Clostridium difficile is a major factor influencing the spread of C. difficile-associated diarrhoea (CDAD) in the clinical setting. In recent years, the antimicrobial efficacy of metal surfaces has been investigated against microorganisms including methicillin-resistant Staphylococcus aureus. This study compared the survival of C. dif...

A highly oxidized form of a chitosan/dextran-based hydrogel (CD-100) containing 80% oxidized dextran aldehyde (DA-100) was developed as a post-operative aid, and found to significantly prevent adhesion formation in endoscopic sinus surgery (ESS). However, the CD-100 hydrogel showed moderate in vitro cytotoxicity to mammalian cell lines, with the DA-100 found to be the cytotoxic component. In or...

A series of bispyridines were examined for their bactericidal activities against in vitro, preformed, pure-culture plaques of selected oral plaque-forming bacteria. The antimicrobial activities of these agents were examined in relation to their molecular configurations. These studies demonstrated that the length of the interpyridine polymethylene group bridge and the length of the alkyl side ch...

BACKGROUND The aim of this study was to perform a systematic review of the literature on the efficacy of antimicrobial photodynamic therapy (PDTa) on cariogenic dental biofilm. TYPES OF STUDIES REVIEWED Studies in vivo, in vitro, and in situ were included. Articles that did not address PDTa, those that did not involve cariogenic biofilm, those that used microorganisms in the plankton phase, a...

Dental caries is an infectious disease of bacterial origin. The use of antimicrobial agents to reduce or eliminate the bacteria associated with caries follows the approach used to combat other infectious diseases of humans. Unfortunately, only a few dozen studies have sufficient resolving power to make inferences as to the anticaries efficacy of the antimicrobial approach to caries management. ...

A guideline on the responsible and prudent use of antimicrobials in animal husbandry has been developed by the Ad hoc Group of experts on antimicrobial resistance, created by the Office International des Epizooties. The objectives of responsible use are to maintain antibiotic efficacy, to avoid the dissemination of resistant bacteria or resistance determinants and to avoid the exposure of human...

Background. Silver has been used for years in the medical field due to its antibacterial efficacy. Silver has been applied topically to fabrics as an antimicrobial agent but the process lacks efficacy because the silver percent is too low. A new yarn which can be used to weave or knit fabrics uses novel technology to extrude the silver into the yarn fibers. This process allows the silver to phy...

Mn( ii ), Co( and Ni( ) morpholine 2,2′-bipyridine complexes gave potent DNA cleavage, antimicrobial antioxidant activity. Calculations support the results, with Co Ni showing better anticancer efficacy than cisplatin.

the antimicrobial efficacy of methanol and water extracts of seeds of the plant swietenia macrophylla (family: meliaceae) was evaluated against selected pathogenic bacterial strains (bacillus cereus mtcc 430, klebsiella penumoniae mtcc 109, pseudomonas aeruginosa mtcc 424, escherichia  coli mtcc 443, staphylococcus aureus mtcc 96, salmonella typhimurium mtcc 98, micrococcus luteus mtcc 106) and...

Uropathogenic organisms have evolved numerous defense mechanisms against antimicrobial agents, hence resistance to old and newly available drugs are increasing at an unprecedented level. The events of antibiotic resistance have lead for screening of several medicinal plants for their potential antimicrobial activity. The aim of this study was to evaluate the antimicrobial efficacy of Cyminumcum...