ArisaemajacquemontiiBlume (Araceae) is reputed for its physiological properties in the folk medicine system and used in Chinese herbal medicine as anti-convulsant. Methanolic extracts of roots and fruits, the chloroform extracts of roots and shoots of ArisaemajacquemontiiBlume were investigated for immunomodulatory,antileishmanialand phytotixic activities. Immunomodulatory activitywas investiga...

Article history: Received on: 04/10/2012 Revised on: 16/10/2012 Accepted on: 21/10/2012 Available online: 29/10/2012 The theoretical docking study, conducted on a sample of previously reported for anti-inflammatory and antioxidant activities of Taxifolin at the binding site of Leishmania infantum trypanothione reductase (Try R) examine interaction energy. Taxifolin is widely used in the traditi...

background: in leishmaniasis, some drugs prescribed for treatment have toxic ef-fects and there are reports about drug resistance in some countries. due to this fact, using herbal drugs such as artemisinin with good efficacy and low toxic effect might be suitable. methods: we evaluated the apoptotic effect of artemisinin on leishmania major in vitro and the antileishmanial activities of artemis...

background and objectives: several natural compounds have been identified for the treatment ofleishmaniasis. due to a few safe drugs and the side effects caused by available chemotherapy, some new drugs for treatment of leishmaniasis are requested.  the genus pulicaria (asteraceae) is represented in the flora of iran by five species. phytochemical studies on pulicaria species have revealed some...

background: leishmaniasis has been identified as a major public health problem in tropical and sub-tropical countries. the present study was aimed to investigate antileishmanial effects of various extracts of berberis vulgaris also its active com-poenent, berberine against leishmania tropica and l. infantum species on in vitro ex-periments. methods : in this study in vitro antileishmanial activ...

We previously reported the effectiveness of trans-aconitic acid (TAA) as an antileishmanial compound. Inhibitory effects of TAA along with other antileishmanial compounds on transformation and in vitro multiplication in macrophage cultures of Leishmania donovani have been assessed. The efficacy of TAA in combined chemotherapy of experimental visceral leishmaniasis has also been evaluated along ...

OBJECTIVES To evaluate the in vitro activity of antileishmanial drugs, paromomycin and miltefosine, to generate Th-1-biased immunomodulation in hosts against intracellular Leishmania donovani. METHODS In silico protein-ligand interaction and in vitro drug-cell interaction assays were performed. Interaction assays of TLR4-deficient HEK293 cells and HEK293 cells engineered to express either TLR...

BACKGROUND Sensitive and glucantime (MA) resistance Leishmania tropica are referred to those isolates, which are responsive, or non-responsive to one or two full courses of treatment by MA systematically and/or intra-lesionally, respectively. In this study, we evaluated the antileishmanial activity of biogenic selenium nanoparticles (Se NPs) alone and in combination with MA against sensitive an...