BACKGROUND Chronic hypertension complicates around 3% of all pregnancies. There is evidence that treating severe hypertension reduces maternal morbidity. This study aimed to systematically review randomized controlled trials of antihypertensive agents treating chronic hypertension in pregnancy to determine the effect of this intervention. METHODS AND RESULTS Medline (via OVID), Embase (via OV...

Previous NBDPS (National Birth Defects Prevention Study) findings from 1997 to 2003 suggested that maternal antihypertensive use was associated with congenital heart defects (CHDs). We re-examined associations between specific antihypertensive medication classes and specific CHDs with additional NBDPS data from 2004 to 2011. After excluding mothers missing hypertension information or who report...

j 1 demonstrated the potentiation of antihypertensive agents by chlorothiazide,1-3 its value alone in patients with moderately severe and severe hypertension has not been established. This investigation was designed to compare the effectiveness of alternate 6-month courses of chlorothiazide alone with standard antihypertensive therapy, and to compare the results of these periods with those of a...

Effectiveness of antihypertensive agents is assessed not only by systemic blood pressure levels, but by multiple parameters that reflect specific organ functions. Among antihypertensive agents, those which inhibit angiotensin actions show particular efficacy in ameliorating end organ damage. This efficacy likely reflects the central role that angiotensin has in regulating renal function by its ...

1. Captopril (100 mg/kg, orally) decreased blood pressure in spontaneously hypertensive (SH) rats. 2. Bilateral adrenalectomy either before or after captopril administration did not alter the antihypertensive effect of captopril. 3. Bilateral nephrectomy reversed the established antihypertensive effect of captopril and prevented any change in blood pressure to a subsequent dose of captopril. 4....

Milk is an important component of a balanced diet and contains many valuable constituents. A considerable part of the milk healthbenefits is related to its proteins, not only for their nutritive value but also for their biological properties. Scientific evidence suggests that anticarcinogenic activities, antihypertensive properties, immune system modulation, and other metabolic features of milk...

background: resveratrol has beneficial effects on cardiovascular system. this study aimed at examining antidiabetic and antihypertensive effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension. methods: eight groups (8-10 each) of male spargue-dawley rats, including a control, a diabetic (induced by streptozotocin and nicotinamide), a renal hypertensive (induced ...

BACKGROUND AND OBJECTIVE Lowering BP to normal levels without quality of life deterioration is the most important means of reducing cardiovascular risk. Recent studies have challenged the position of beta-adrenoceptor antagonists (beta-blockers) as first-line antihypertensive drugs. Nebivolol is a third-generation, highly selective beta(1)-blocker that causes vasodilation through nitric oxide (...

To evaluate the impact of various regimens antihypertensive treatment on blood pressure and target organs in nonadherent hypertensive patients.

Rationale The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), sponsored by the National Heart, Lung, and Blood Institute (NHLBI), is the largest outcome trial of antihypertensive treatment ever carried out and the only large blood pressure (BP) trial to be carried out in a US population in the past decade.1 The rationale for ALLHAT, which was designed in th...