This study aimed to enhance γ-aminobutyric acid (GABA) in pigeon pea milk (CCM). The drink was prepared from germinated and fermented using the probiotic Lactiplantibacillus plantarum Dad-13. Various nutrients significantly increased GABA content milk, i.e., sucrose 3% (4409 mg/L), monosodium glutamate (MSG) 1% (59,562 whey 4% (5283 respectively. Glutamate decarboxylase (GAD)-encoding genes wer...

Polyamines (PAs) are involved in various developmental processes, especially plant flowering. Their significant influences have been established; however, the exact mechanism by which PAs regulate flowering remains unclear. To explore PA metabolism flowering, gibberellic acid (GA3, 0~2400 mg L?1) and spermidine (Spd, 0~1 mM) were applied alone or combination during early stage of flower bud for...

Lactobacillus plantarum is a lactic acid bacterium able to degrade tannins by the subsequent action of tannase and gallate decarboxylase enzymes. The gene encoding tannase had previously been identified, whereas the gene encoding gallate decarboxylase is unknown. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of gallic-acid induced L. plantarum extracts showed a 54-kDa pro...

glutamate decarboxylase enzyme produces γ-aminobutyric acid (gaba) in a non-reversible decarboxylation reaction of glutamate. gaba is a major inhibitory neurotransmitter of the brain and it is also present at high concentration in other organs such as pancreatic islets. gaba has effects on blood pressure, diabetes, inflammation, sleeplessness and depression. some bacteria such as lactobacillus ...

BACKGROUND & OBJECTIVES Several autoimmune disorders have been reported to be associated with autoimmune thyroiditis and may coexist with other organ-specific autoantibodies. The aim of the present study was to evaluate the presence of tissue transglutaminase (anti-TTG) and glutamic acid decarboxylase (anti-GAD) antibodies in patients suffering from autoimmune thyroiditis as diagnosed by anti-t...

A method of determining histidine decarboxylase activity was established. In this method, 14C-histamine was separated from 14C-histidine by Amberlite CG-resin column in the ammonium form. Lecanoric acid was obtained by screening histidinedecarboxylase inhibitors produced by microorganisms. It is the first isolation of this compound from fungi. The inhibition by lecanoric acid was competitive wi...

Glutamic acid decarboxylase (GAD) is an enzyme which converts the glutamic acid to the neurotransmitter gamma-amino butyric acid (GABA). GABA is an inhibitory neurotransmitter that inhibits or weakens the neuronal stimulations. Presynaptic GABAergic neurons in the central neurons system (CNS) and the cells in the islets of Langerhans in the pancreas generate GAD. There are two isoforms of GAD n...

Among paraneoplastic neurologic disorders (PND), opsoclonus-myoclonus syndrome, so-called "dancing eye syndrome," is a rare disorder combining multivectorial eye movements, involuntary multifocal myoclonus, and cerebellar ataxia. Although several paraneoplastic antibodies against postsynaptic or cell-surface antigens have been reported, usually most patients are serum antibody negative. We repo...

Background: Gamma -aminobutyric acid (GABA), a non-protein amino acid acts as an inhibitory neurotransmitter in the central nervous system of mammalians. The glutamate decarboxylase (GAD) is responsible for the conversion of L-glutamate to GABA. The human brain has two isoforms of this enzyme, GAD65 and GAD67 that differ in molecular weight, amino acid sequence, antigenicity, cellular location ...