Ephrin-B2 is predominately expressed in endothelium of arterial origin, involved in developmental angiogenesis and neovasculature formation through its interaction with EphB4. Despite its importance in physiology and pathological conditions, it has been challenging to produce monoclonal antibodies against ephrin-B2 due to its high conservation in sequence throughout human and rodents. Using a n...

The fate of two recently described human B lymphocyte-specific antigens (B1 and B2) was studied after B-cell activation in vivo and in vitro. Whereas both B1 and B2 were present on virtually all B cells from normal lymph nodes, B2 was absent from approximately 50% of B cells from hyperplastic lymph nodes. When B cells from spleen, tonsil, or peripheral blood were stimulated in vitro with pokewe...

Bovine papillomavirus type 1 (BPV-1) requires viral proteins E1 and E2 for efficient DNA replication in host cells. E1 functions at the BPV origin as an ATP-dependent helicase during replication initiation. Previously, we used alanine mutagenesis to identify two hydrophilic regions of the E1 DNA binding domain (E1DBD), HR1 (E1(179-191)) and HR3 (E1(241-252)), which are critical for sequence-spe...

Background The mechanisms behind residual platelet reactivity (RPR) despite aspirin treatment are not established. It has been shown that coronary artery disease (CAD) patients with high on-aspirin RPR have elevated levels of von Willebrand factor (vWF). ADAMTS13 is a metalloprotease cleaving ultra large vWF multimers into less active fragments.Our aim was to investigate whether ADAMTS13 and vW...

U.S. PATENT DOCUMENTS 5,012,052 A 4/1991 Hayes 5,338,930 A 8/1994 Chu et al. 5,965,884 A 10/1999 Laiko et al. 6,495,824 B1 12/2002 Atkinson 6,531,318 B1 3/2003 Palmer-Toy et al. 6,548,263 B1 4/2003 Kapur et a1. 6,558,946 B1 5/2003 Krishnamurthy 6,656,690 B2 12/2003 Crooke et al. 6,744,046 B2 6/2004 Valaskovic et a1. 6,941,033 B2 9/2005 Taylor et a1. 6,949,741 B2 9/2005 Cody et a1. 6,989,528 B2 ...

The sinterability, microstructure, and mechanical properties of pure TiB2- CrB2-doped ZrB2 prepared by spark plasma sintering were investigated. solid solutions synthesized the complete borothermal reduction to form (Zr0.95Ti0.05)B2 (Zr0.95Cr0.05)B2. results showed that solution yielded smaller particle size than sinterability was also improved with use solutions, as evidenced an increase relat...

This paper presents a study of the semidirectly closed pseudovariety generated by the aperiodic Brandt semigroup B2, denoted V(B2). We construct a basis of pseudoidentities for the semidirect powers of the pseudovariety generated by B2 which leads to the main result, which states that V(B2) is decidable. Independently, using some suggestions given by J. Almeida in his book “Finite Semigroups an...

5,987,444 A 11/1999 Lo 6,157,811 A 12/2000 Dent 6,307,959 B1 10/2001 Mandelbaum et al. 6,522,991 B2 2/2003 Banaszuk et al. 7,172,897 B2 2/2007 Blackburn et al. 7,203,555 B2 4/2007 Ogunnaike et al. 7,650,181 B2 1/2010 Freeman et al. 7,831,094 B2 11/2010 Gupta et al. 7,917,332 B2 3/2011 Waldock et al. 2002/0162317 Al 11/2002 Banaszuk et al. 2004/0053290 Al 3/2004 Terbrueggen et al. 2005/0238200 A...