LeuT is a member of the neurotransmitter/sodium symporter family, which includes the neuronal transporters for serotonin, norepinephrine, and dopamine. The original crystal structure of LeuT shows a primary leucine-binding site at the center of the protein. LeuT is inhibited by different classes of antidepressants that act as potent inhibitors of the serotonin transporter. The newly determined ...

This study assessed trends in prices at market entry of antidepressant drugs approved by the US Food and Drug Administration (FDA) 1978-2020. Antidepressant regulatory information was derived from FDA website. Indications Defined Daily Dose (DDD) were labels. wholesale acquisition cost (WAC) data extracted IBM Micromedex Redbook approval date to December 31, 2020. The consumer price index (CPI)...

UNLABELLED Depression is common in reproductive age women, and continued pharmacologic treatment of depression during pregnancy may be necessary to prevent relapse, which could be harmful for both the fetus and the mother. Although data on drug safety are imperfect and incomplete, the benefits of antidepressant therapy during pregnancy generally outweigh the risks. Neonates who are exposed to a...