A retrospective survey of the records of 287 patients with generalised myasthenia gravis treated at New End Hospital and later at the Royal Free Hospital by anticholinesterase drugs, with or without thymectomy, between the years 1942 and 1976, shows that 62% of patients were improved. The timing of the operation, the grading of disease and the age and sex of the patient did not greatly influenc...

The article highlighted in this issue is "Dizocilpine Improves Beneficial Effects of Cholinergic Antagonists in Anticholinesterase-Treated Mice," by Andrzej Dekundy, Rafal M. Kaminski, and Waldemar A. Turski (pp. 289-295). It explores the relationship between cholinergic and N-methyl-D-aspartate (NMDA) receptors as mediators of anticholinesterase toxicity. The following review summarizes these ...

Hesperis isatidea (Brassicaceae) is a perennial herbaceous endemic plant known as “Allıgelin”. It has traditional use concerning the cough, wound, cold and vulnerary in form of decoction poultice Eastern Turkey. In this study, vitro antioxidant activity (DPPH, ABTS, FRAP, metal chelating) enzyme inhibitory activities (anticholinesterase, anti-tyrosinase) H. isatideae were evaluated. Besides, tr...

The aim of this study was to investigate in vitro antioxidant, anticholinesterase and antibacterial activities of the petroleum ether, chloroform and methanol extracts obtained from the aerial parts of Jurinea consanguinea DC. (Asteraceae). Total phenolic and flavonoid contents of these crude extracts were determined as pyrocatechol and quercetin equivalents, respectively. The methanol extract ...

Is it always necessary to antagonize residual neuromuscular block? Do children differ from adults? Use of an anticholinesterase at the end of surgery, to antagonize residual neuromuscular block induced by a non-depolarizing drug, is commonplace; it is easy to forget that such drugs were not always given routinely. When the clinical use of " Intocostrin " (a biologically standardized extract of ...