In Leishmania (L.) major-infected BALB/c mice Th2-type cells results in disease progression, whereas C57BL/6-infected mice mount a Th1-type response, which leads to control of the infection. Th2 response correlates with IgG1 whereas, Th1 response supports switching to IgG2a subclasses. Since IgG isotype-dominated response depends on different CD4 + T cell subsets, we studied the antigenic profi...

An inactivated trivalent fowl cholera vaccine consisted of serotypes 1, 3 and 4 Pasteurella multocida strains was prepared. The vaccine provided 70-100% protection against challenge with homologous starins. ELISA assay showed a considerable increase in antibody titer after towice vaccination of 8 weeks chickens. It was found that the trivalent vaccine can induce immunogenic response in vaccinat...

Limbic encephalitis is an adaptive autoimmune disease, induced by different autoantibodies, which target extracellular neuronal epitopes, such as NMDA or GABAB receptors1,2. Recently our group found another human antibody, which binds to the α1 subunit of the GABAA receptor. Since the GABAA receptor is responsible for the majority of fast inhibitory neurotransmission, we investigated chan...

  Humoral immune response of vaccine-I (supermatent from sonicated sporulated oocyst), vaccine –II (sediment from sonicated sporulated oocyst) and vaccine –III (un-sonicated sporulated oocyst) against conccidiosis in chickens was determined by indirect haemagglutination (IHA) test. IHA antibody titre was significantly higher (p

objective: several vaccines against hiv have been investigated but none has been approved as an effective hiv vaccine. an approach that could induce stronger immune response against the pathogen is utilizing a multi-epitopic vaccine. this strategy was used in the design of several vaccines and resulted in improved immune responses. materials and methods: in this study a multi-epitopic fusion p...

1AJBORATORY EVALUATION of the J efficacy of typhoid vaccine has generally produced results which show little correlation with those obtained in field-trial evaluation. Hence, extensive field trials have been deemed necessary to evaluate the various typhoid vaccines {1-S). Recent advances in immunological methodology have demonstrated distinct classes of immunoglobulins with differing bio¬ logic...

ment. An introductory section of this chapter deals with criteria of endocrine function and methods and difficulties encountered in studying endocrine problems. This is a useful part of the book and should be of value to the student. Whereas the first two chapters deal at a general level with the topics of osmoregulation and endocrine control, the following chapters cover the function of these ...

Background: Due to their similar routes of transmission, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infection occurs considerably. HBV infection progresses more rapidly in HIV-infected patients. Therefore, HBV vaccination of all non-immune HIV infected patients is recommended. On the other hand, HIV-infected subjects have suboptimal responses to HBV vaccine. In this study...

We conducted a prospective pilot study of the serologic responses to overlapping recombinant fragments of the Pneumocystis jirovecii major surface glycoprotein (Msg) in HIV-infected patients with pneumonia due to P. jirovecii and other causes. Similar baseline geometric mean antibody levels to the fragments measured by an ELISA were found in both groups. Serum antibodies to MsgC in P. jirovecii...