Variable Common Immune Deficiency (VCID) is a very heterogeneous condition both clinically and immunologically. It group of molecular abnormalities responsible for defect in antibody production leading to hypogammaglobulinemia often associated with autoimmune and/or lymphoproliferative manifestations. Late Onset Combined (LOCID) type defined by (IgG IgA ± IgM type), profound CD4 T-cell lymphope...

The trace element zinc is an essential micronutrient for the proper functioning of the immune system. Zinc deficiency leads to impaired function of the unspecific and specific immune response and consequently to an increased susceptibility to bacterial, viral and fungal infections. Immunological defects are not only seen in pronounced but even in marginal and moderate zinc deficiency. Lack of z...

Nutritional deficiency reduces antibody synthetic capacity. Antibody directed against tumor antigens, however, may serve either to heighten tumor immunity, as in antibody-dependent cellular cytotoxicity, or to diminish host resistance to cancer growth by "blocking" cell-mediated tumor immunity. Diets made deficient in specific amino acids are inimical to tumor growth, apparently through reducti...

BACKGROUND While primary immunodeficiencies (PID has been recognized in the west for decades, recognition has been delayed in the third world. This study attempts to detail the spectrum of PID, the therapy provided, and constraints in the diagnosis and treatment in a middle income country such as Sri Lanka. METHODS Nine hundred and forty two patients with recurrent infections and features sug...

epidemiological studies have shown wide geographical and racial variation in the prevalence and patterns of immunodeficiency disorders. to determine the frequency of primary immunodeficiencies (pid) in iran, the iranian primary immunodeficiencies registry (ipidr) was organized in 1999. the diagnosis of immunodeficiency in our patients was based on standard criteria. the patient’s data were extr...

celiac disease has protean manifestations. in this report, a 24 year-old young female with celiac disease and acute lower extremity deep venous thrombosis (dvt) is presented. the patient was a 24 year-old female who presented with long standing diarrhea, 8 kg weight loss in the recent month, lower extremity edema, petechiae and purpura. laboratory exam demonstrated very high titers of iga antie...

BACKGROUND Respiratory infections are major causes of morbidity and mortality, but determinants of susceptibility are poorly defined. We studied whether and to what extent immunologic and genetic factors are associated with increased susceptibility to respiratory infections. METHODS We evaluated the prevalence of IgA, IgM, IgG, and IgG subclass deficiencies, impairment in the antibody respons...