Methicillin-resistant Staphylococcus aureus (S. aureus) (MRSA), resistant to all antibiotics including Vancomycin, has been reported in Japan, USA, Canada and Brazil. Hence, the main objective of this study was to evaluate the possible presence of Vancomycin resistant or intermediate S.aureus in Karachi. A total of 850 clinical isolates were collected from two civil hospitals in the city betwee...

OBJECTIVES Bactericidal activity depends on antibiotic-bacteria couples, resistance phenotype and theoretically on protein binding. This work explores the influence of protein binding on the bactericidal activity of two antibiotics, daptomycin versus vancomycin, that exhibit, respectively, different C(max) (56 versus 25.5 mg/L), protein binding (91.7% versus 36.9%) and thus theoretical free-dru...

Drug-resistant tuberculosis, in particular Multi-Drug Resistant (MDR-TB) is an increasing global concern and a major burden for some developing countries, especially the BRICS. It is assumed that every year roughly 350 000 new MDR-TB cases occur in the world, on average in 20.5% of TB patients that have been previously treated but also in 3.5% of persons that have never been on TB treatment bef...

OBJECTIVES A national survey was conducted to determine the prevalence and risk factors of methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum β-lactamases-producing Enterobacteriaceae (ESBLE) and vancomycin-resistant enterococci (VRE) among nursing home residents in Belgium. METHODS A random stratified, national prevalence survey was conducted in nursing home residents who ...

Neplanocin A (1)1 and aristeromycin (2)2 are representatives of naturally occurring carbocyclic nucleosides, which exhibit interesting biological activity3 (Figure 1). These compounds act as potent inhibitors of S-adenosylhomocysteine (SAH) hydrolase, which catalyzes the hydrolysis of S-adenosylhomocysteine into adenosine and homocysteine.4 Inhibition of the SAH hydrolase accumulates S-adenosyl...

introduction: stumbling or falling is a major health problem among the elderly which accounts for their majority of physical injuries such as pelvic fractures, disability, loss of independency and even death. the goal of the study was comparison of the effect of aerobic and resistance exercise on static and dynamic balance in old men. methods: a quasi-experimental study was conducted and thirty...

there is a great concern about the effect of propoxur, as one of the more common n-methyl carbamate pesticides, on human health due to its extensive use in agricultural and non-agricultural applications. caco-2 cells became resistant to propoxur, and the resistance was confirmed through mtt assay. then the cell membrane integrity and p-glycoprotein expression were measured by ldh assay and west...

nosocomial infections of multidrug-resistant pseudomonas aeruginosa (mdrpa) are a growing concern in hospitalized patients in burn centers. the aim of this study was to investigate the flagellin profiling and antibiotic susceptibility of p. aeruginosa isolated from burn wound infections. during 8 month study, 73 clinically p. aeruginosa isolates collected from patients hospitalized in burn ward...

conclusions the relative higher frequency of some virulence genes in this study may reflect the emergence of isolates containing these genes in shiraz medical centers. background staphylococcus aureus is amongst major human pathogens both in hospitals and the community. this bacterium is an opportunistic pathogen responsible for a large number of self-limiting and even life-threatening diseases...

background staphylococcus aureus is a common cause of infections among humans and animals and it is known as a community-acquired and nosocomial pathogen. most of the isolates contain lysogenic phages which are responsible for production of various virulence factors such as enterotoxins, staphylokinase, β-lysin, lipase, exfoliative toxin a and pantone-vlaentine leukociden (pvl). all staphylococ...