conclusions methicillin resistance is a specialized concern in clinical studies, and it is mandatory to detect this mechanism by an accurate method that is updated periodically. increasing the resistance of s. aureus to multiple antibiotics underlines the need for intermittent resistance surveillance. results methicillin resistance was detected in 38% of s. aureus isolates, confirmed by the aga...

Growing resistance to antibacterial agents has increased the need for the development of new drugs to treat bacterial infections. Given increasing pressure on limited health budgets, it is important to study the cost-effectiveness of these drugs, as well as their safety and efficacy, to find out whether or not they provide value for money and should be reimbursed. In this article, we systematic...

This article highlights current trends and advances in exploiting natural sources for the deployment of novel and potent anti-infective countermeasures. The key challenge is to therapeutically target bacterial pathogens that exhibit a variety of puzzling and evolutionarily complex resistance mechanisms. Special emphasis is given to the strengths, weaknesses, and opportunities in the natural pro...

BACKGROUND Multi-drug resistance of Gram-negative bacteria constitutes a major obstacle in the antibacterial fight worldwide. The discovery of new and effective antimicrobials and/or resistance modulators is necessary to combat the spread of resistance or to reverse the multi-drug resistance. In this study, we investigated the antibacterial and antibiotic-resistance modifying activities against...

From a public health perspective, new antibacterial agents should be evaluated and approved for use before widespread resistance to existing agents emerges. However, for multidrug-resistant pathogens, demonstration of superior efficacy of a new agent over a current standard-of-care agent is routinely feasible only when epidemic spread of these dangerous organisms has already occurred. One solut...

antibacterial drugs used in animal might result in deposition of residues in meat, milk and eggs. the presence of antimicrobial residues in animal-originated food is critical problem in many countries over the years. because, drug residues might result in various health hazards, both actual incidence of reactions and potential hazards perceived by the public, the most countries assess residue o...

ABSTRACT EVALUATING RISKS FROM ANTIBACTERIAL MEDICATION THERAPY USING AN OBSERVATIONAL PRIMARY CARE DATABASE Sharon B. Meropol Joshua P. Metlay Virtually everyone in the U.S. is exposed to antibacterial drugs at some point in their lives. It is important to understand the benefits and risks related to these medications with nearly universal public exposure. Most information on antibacterial dru...

Infectious diseases are the major cause of morbidity and mortality caused by Pseudomonas aeruginosa (P. aeruginosa) and Acinetobacter baumannii (A. baumannii) and have successfully evolved numerous strategies for resisting the action of many antibacterial drugs. They harbor several drug resistant mechanisms such as target alteration, efflux pump, low intrinsic susceptibility and cross-resistanc...

background: antibiotic resistant bacteria can be considered as a main problem in infection management. zinc oxide nanoparticles (zno nps), individually or in combination with antibiotics, can be considered as good candidates for struggling against drug resistant bacteria. methods: in this study, zinc oxide nanoparticles were synthesized using sol-gel method in low temperature as a cost effectiv...

background: nosocomial infections are one of the most important medical problems in developed and under developing countries which cause the spread of infections diseases in society. pseudomonas aeroginosa is one of the most important causes of hospital infections, especially in wounds from operated patients. increase in antibiotic-resistance of pseudomonas aeroginosa cause a lot of problems fo...