BACKGROUND A woman's candidacy for Rh immune globulin depends on whether her blood type is Rh-positive (D antigen-positive) or Rh-negative (D antigen-negative). New molecular blood-typing methods have identified variant D antigens, which may be reported as Rh-positive or Rh-negative depending on the laboratory method. We describe a case illustrating the effect of the new laboratory methods on a...

Haemolytic disease of the fetus and newborn (HDFN) may occur when maternal IgG antibodies against red blood cells (RBCs), often anti-RhD (anti-D) antibodies, cross the placenta and mediate the destruction of RBCs via phagocytic IgG-Fc-receptors (FcγR). Clinical severity is not strictly related to titre and is more accurately predicted by the diagnostically-applied monocyte-based antibody-depend...

By R. R. RACE, M.R.C.S., L.R.C.P., A. E. MOURANT, B.M., B.Ch., MA., D. Phil., SYLVIA D. LAWLER, M.W, B.S., and RUTH SANGER, B.Sc.* T HIS paper reports the results of testing 1073 samples of blood, from English people, with the Rh antibodies anti-C, anti-C”, anti-c, anti-D, anti-E and anti-c. To these are added another 92.7, tested with anti-C, anti-c, anti-D and antiE, the results of which have...

T HE D ANTIGEN has been detected on the surface of Rh( D) leukocytest by a variety of indirect technics. Dausett, Colombani and Evelin1 used the methods of antiglobulin consumption and anti-D absorption by leukocytes. Jankovi#{233} and Lincoln showed fluorescence of Rh(D) leukocytes with fluorescein conjugated antihuman globulin after the exposure of leukocytes to anti-D serum. Hollman was able...

INTRODUCTION Hemolytic disease of the newborn was first described in the medical literature 1609, when it was diagnosed in one French housewife. In 1932 Diamond and colleagues described the mutual relationship of fetal hydrops, jaundice, anemia and erythoblastosis, which was later called fetal erytroblastosis. Hemolytic disease of the newborn (HDN) in the strict sense is considered disease whos...

Anti-D is routinely and effectively used to prevent hemolytic disease of the fetus and newborn (HDFN) caused by the antibody response to the D antigen on fetal RBCs. Anti-D is a polyclonal IgG product purified from the plasma of D-alloimmunized individuals. The mechanism of anti-D has not been fully elucidated. Antigenic epitopes are not fully masked by anti-D and are available for immune syste...

By R. R. RACE, M.R.C.S., L.R.C.P., A. E. MOURANT, B.M., B.Ch., MA., D. Phil., SYLVIA D. LAWLER, M.W, B.S., and RUTH SANGER, B.Sc.* T HIS paper reports the results of testing 1073 samples of blood, from English people, with the Rh antibodies anti-C, anti-C”, anti-c, anti-D, anti-E and anti-c. To these are added another 92.7, tested with anti-C, anti-c, anti-D and antiE, the results of which have...