Tumor-specific TCR can serve as an effective target for active immunotherapy of T cell malignancies. Using the murine T cell tumor model C6VL, vaccination with C6VL TCR protected mice from a subsequent lethal dose of tumor cells. This study characterizes the immune mechanisms involved in the tumor protection, and the influence of immunologic adjuvants in inducing a protective immune response. I...

Objective: The emergence of multi-drug-resistant pathogens on antimicrobials in current use has made it necessary to search for alternative treatment strategies. Plant essential oils are considered as the diseases because they non-toxic, cost-effective and accessible. This study aimed evaluate antibacterial antibiofilm effect anti-quarum sensing (QS) properties Cinnamomun verum leaf oil Pseudom...

Abstract. Arab Y, Sahin B, Ceylan O, Zellagui A, Olmez OT, Kucukaydin S, Tamfu AN, Ozturk M, Gherraf N. 2022. Assessment of in vitro activities and chemical profiling Senecio hoggariensis growing Algerian Sahara. Biodiversitas 23: 3498-3506. The antioxidant, anticholinesterase, tyrosinase inhibitory, antibiofilm, anti-quorum sensing the ethyl acetate extract hoggariensis,growing Sahara, were st...

Some bacteria produce and perceive quorum-sensing (QS) signals that coordinate several behaviours, including the costly processes that are exoenzyme production and plasmid transfer. In the case of plasmid transfer, the emergence of QS signal-altered invaders and their policing are poorly documented. In Agrobacterium tumefaciens, the virulence Ti-plasmid encodes both synthesis and sensing of QS-...

Ebola virus (EBOV), a member of the Filoviridae that can cause severe hemorrhagic fever in humans and nonhuman primates, poses a significant threat to the public health. Currently, there are no licensed vaccines or therapeutics to prevent and treat EBOV infection. Several vaccines based on the EBOV glycoprotein (GP) are under development, including vectored, virus-like particles, and protein-ba...

We develop a multiphasic hydrodynamic theory for biofilms taking into account interactions among various bacterial phenotypes, extracellular polymeric substance (EPS), quorum sensing (QS) molecules, solvent, and antibiotics. In the model, bacteria are classified into down-regulated QS, up-regulated QS, and non-QS cells based on their QS ability. The model is first benchmarked against an experim...

The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in vitro and in animal models of infection and is considered an ideal target for the development of anti-virulence agents. However, the precise role played by each individual component of this complex QS circuit in the control of virulence remains to be elucidated. Key components of the pqs QS system are 2-h...

OBJECTIVE To investigate the effects of quercetin in a model of bleomycin-induced pulmonary inflammation and fibrosis. METHODS Seventynine adult male hamsters were randomized to receive intratracheal (IT) instillations and intraperitoneal (IP) injections in four configurations: IP vehicle/IT saline (VS group, n = 16); IP quercetin/IT saline (QS group, n = 16); IP vehicle/IT bleomycin (VB grou...

0. Introduction Phonological representations include sequences of featural specifications, pq. Two properties can be observed about such sequences: (i) for a sequence pq to be of significance for the phonology of a language, p must be perceptibly different than q; (ii) to produce a sequence pq, the articulators must start in the configuration for p and then change into the configuration for q. ...

In this note the notion of interval-valued fuzzy QS-algebra (briefly, i-v fuzzy QS-algebra), as well as the i-v level and strong i-v level QS-subalgebra is introduced. Several theorems which determine the relationship between these notions and QS-subalgebras are stated and proved. The images and inverse images of i-v fuzzy QS-subalgebras are defined, and how the homomorphic images and inverse i...