nigella sativa (n. sativa) grows in various parts of the world, particularly in iran. it has been traditionally used as a folk remedy to treat a number of diseases. the seeds of this plant contain moisture, proteins, carbohydrates, crude fiber, alkaloids, saponins, ash, fixed oils and essential oil. the major components of the essential oil are thymoquinone, p-cymene, trans-anethole, 2-methyl-5...

to determine the presence of anticardiolipin (acl) antibodies in patients with ischemic events, we designed a case-control study. we studied 33 patients with unstable angina, 33 male patients with myocardial infarction and 34 control subjects with no evidence of ischemic heart disease. plasma samples were assessed for igg anticardiolipin antibodies by enzyme-linked immunosorbent assay (elisa). ...

background: stroke is a leading cause of death all around the world, and ischemic stroke is considered to be the most common stroke type. toll-like receptors (tlrs) are important molecules for detection of both pathogen invasion and tissue damage. in this regard, the purpose of this study was to assess the expression level of tlr2 on monocytes in patients with ischemic stroke and to evaluate th...

Background: The current case report aimed at describing the clinical, radiological, and immunological findings of a case of ischemic stroke due to acute thrombosis of the left internal carotid artery and multiple watershed infarctions mimicking Multiple Sclerosis (MS). Clinical Presentation and Intervention: A 24-year-old right-handed Iranian female was initially diagnosed with Multiple Sclero...

BNG-1, a novel mixture of traditional Chinese medicines with a long history in the treatment of stroke, exhibited acute neuroprotection effect on rats with middle cerebral artery occlusion (MCAO). Anti-ischemic effects were seen in both animals receiving BNG-1 before the ischemic insult as well as in animals receiving the drug formulation after surgical occlusion of the artery. Anti-thrombic ac...

The ischemia-reperfusion-induced damage in human brain microvascular endothelial cells (BMECs) is associated with disruption of the blood–brain barrier. CXC chemokine ligand 5 (CXCL5) reported to be up-regulated ischemic stroke. However, detailed function CXCL5 this pathological process remains largely unclear. To further analyze stroke, an oxygen–glucose deprivation model on BMECs was construc...

Alterations in cardiac metabolism are present in ischemic heart disease and heart failure, suggesting an increased utilization of non carbohydrate substrates for energy production, with a reduction in the efficiency of myocardial oxygen consumption and ischemia-reperfusion damage. A direct approach to the manipulation of cardiac energy metabolism consists in modifying substrate utilization. Tri...

Ischemic stroke is the leading cause of disability and second death worldwide. However, current therapeutic strategies are scarce limited efficacy. The abundance information available on molecular pathophysiology ischemic has sparked considerable interest in developing new neuroprotective agents that can target different events cascade may be used combination with existing treatments. In this r...

Ischemic stroke is a common cause of permanent disability in adults worldwide. Inflammation plays a significant role in the pathogenesis of ischemic stroke and its mechanism is complex. Both pro-inflammatory and anti-inflammatory mediators are involved in the pathogenesis of ischemic stroke, an imbalance of which leads to inflammation. Inflammatory cells from both the innate and acquired immune...