A double-blind controlled comparative trial of Dothiepin was carried out in Psychiatric Hospital, for comparing its efficacy with that of Imipramine, in the treatment of depression and also to compare the incidence and severity of side effects of the two drug;. Dothicpin hydrochloride is a tricyclic anti-depressant drug with pharmacological properties common to Imipramine Amitryptline and relat...

Purpose: The study aimed to assess the depressant or antidepressant effects of several Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in mice: the selective cyclooxygenase-2 (COX-2) inhibitor meloxicam, and the non-selective COX-1 and COX-2 inhibitors lornoxicam, sodium metamizole, and ketorolac. The current literature data regarding such effects of these agents are scarce. Materials and methods...

BACKGROUND Although prison inmates are reported to exhibit elevated rates of depressive disorders, little is known about anti-depressant prescribing patterns in correctional institutions. METHODS The study population consisted of 5305 Texas Department of Criminal Justice (TDCJ) inmates who were diagnosed with one of three depressive disorders: major depression, dysthymia, and bipolar disorder...

Whether prenatal stress (PNS) and gonadal hormones may influence depressive behavior of rats in the forced swim test was investigated. In Experiment I, adult diestrous female rats had increased immobility, which is indicative of depression, but did not show any significant difference in the duration of struggling compared to intact adult males. In Experiment 2, the behavior of adult intact, cas...

Jieyu chufan (JYCF) is a well-known Chinese traditional medicine used for depression; however, the molecular mechanism underlying its anti-depressant action has remained elusive. In the present study, the anti-depressant effects of JYCF and the potential mechanisms were investigated in a mouse model. Five groups of 12 C57BL/6 mice each were used in the study, including a normal control group (N...

CONTEXT Depression, a sustained mood disorder caused by selective diminution of specialized cells in brain is increasing at an alarming rate. It will be the second largest morbid illness by next decade and is the leading cause of suicidal deaths. The available antidepressant medications benefit only a third of its recipients and have many side effects. Hence, it is imperative to search in Ayurv...

a twelve-year-old girl with disseminated tuberculosis was complicated by psychogenic vomiting and multiple drugs’ adverse effects. she was admitted to our hospital, complaining of fever, cough and abdominal pain. diagnosis of tb was obtained by abdominal ct-scan and open liver biopsy. during the anti-tb treatment, hepatitis, hemolytic anemia and pancreatitis occurred due to some drugs' side eff...

Mild to moderate depression (MMD) is becoming a health burden due its increasing prevalence. Current treatment options are not effective in all patients. Hence, researchers have studied herbal options. It has emerged research that saffron can be used for the of MMD anti-depressant properties. This literature review focussed on by comparing placebo and current antidepressants. Overall, shown red...