objective(s):bacterial biofilm has been considered responsible for many deaths and high health costs worldwide. their better protection against antibacterial agents compared to free living cells leads to poor treatment efficiency. nanotechnology is promising approach to combat biofilm infections. the aim of the present study was to eradicate staphylococcus epidermidis biofilm with silver nanopa...

Defensin from a beetle, Allomyrina dichotoma, is known to have anti-bacterial activity against Gram-positive bacteria. This peptide, which comprises 43 amino acid residues, was effective against methicillin-resistant Staphylococcus aureus. We identified the active site of beetle defensin by measuring anti-bacterial activity against S. aureus of 64 overlapping 12-mer peptides with either a free ...

Several new 2-(2-(4-chlorophenyl)acetyl)-N-arylhydrazinecarbothioamides 1, 5-(4-chlorobenzyl)-4-aryl-4H-1,2,4triazole-3-thiols 2, 5-(4-chlorobenzyl)-N-aryl-1,3,4-thiadiazol-2-amines 3 and 5-(4-chlorobenzyl)-N-aryl-1,3,4-oxadiazol-2amines 4 have been synthesized and screened for their antibacterial activity against gram +ve and gram –ve bacteria i.e S.aureus and E. coli. The QSAR studies of thes...

there is the need for new drugs with better action and lesser side effects. a lot of research is being undertaken to find out new plant drugs, their extraction and pharmacological evaluation. one of such plant is curcuma aromatica whichbelongs to the genus curcuma and reported to have high ethno-botanical values in traditional medicine. the present study evaluates comparative pharmacological ac...