Cardioprotective effect of saffron total glycoside tablets in patients with breast cancer receiving anthracycline-based chemotherapy: study protocol for a multicentre, randomised, parallel, double-blind, placebo-controlled clinical trial

(range 9–53%) with a median OS of 11.0 months (range 5.3– 18.1 months). The advantages of capecitabine are well documented and include good efficacy, tolerability with minimal grade 3–4 toxicity, oral preparation, maintaining quality of life, and cost effectiveness [6]. Another commonly employed option is vinorelbine, which in anthracycline and taxane pretreated patients, yields response rates ...

The anthracycline antitumor antibiotics are important chemotherapeutic agents for the treatment of leukemias, lymphomas, breast cancer, myeloma, small-cell lung cancer, sarcomas, bladder cancer, and pediatric solid tumors. However, the clinical usefulness of the anthracycline antibiotics is limited by their cardiac toxicity, and clinicians confront a clinical dilemma as they balance the efficac...

Anthracycline antibiotics are potent anticancer drugs widely used in the treatment of solidtumors and hematological malignancies. Because of their extensive clinical use and their toxiceffect on normal cells, in the present study the effect of these drugs on multipotent hematopoieticbone marrow cells was investigated employing, viability tests, PARP cleavage, Hoechst 33258staining, DNA fragment...

Intrinsic or acquired drug resistance is a major impediment to the successful treatment of women with breast cancer using chemotherapy. We have observed that MCF-7 breast tumor cells selected for resistance to doxorubicin or epirubicin (MCF-7DOX2 and MCF-7EPI cells, respectively) exhibited increased expression of several members of the aldo-keto reductase (AKR) gene family (in particular AKR1C3...