Background: A retrospective cohort study was conducted to compare the efficacy and safety of direct oral anticoagulants (DOACs) vitamin K antagonists (VKAs) in treatment patients with left ventricular thrombus (LVT).

the effect of nmda (n-methyl-d-aspartate) receptor antagonists on tolerance to morphine antinociception was investigated in mice. daily subcutaneous administration of 50 mg/kg of morphine hydrochloride for three days induced tolerance to different (3,6 and 9 mg/kg) test doses of morphine. the tolerance obtained was decreased by pretreatment of animals with single or repeated doses of competitiv...

Primary dysmenorrhea describes the intensely painful uterine contractions experienced during menstruation. It is associated with elevated prostaglandin production in area and primarily affects adolescents. There are several treatment options available for primary dysmenorrhea, however, there a lapse research assessing their efficacy reliability. The purpose of this review to provide an overview...

  In this study, we investigated the effect of nicotinic receptor agonists and antagonists on the analgesic response to morphine in the formalin test. In experiments conducted in mice, nicotine produced an early dose-dependent analgesic effect. At a dose of 0.5 mg/kg, mecamylamine, a nicotinic receptor inhibitor, suppressed the analgesic effect induced by 0.1 mg/kg nicotine in both stages of th...

A new class of agents has been made available for the treatment of hypertension. These calcium antagonists have rapid bioavailability and dramatic antihypertensive effects through reduction of total peripheral resistance and the vascular resistance of the major target organs of the body. These changes are usually associated with unchanged cardiac output, preserved organ blood flows, maintained ...