antibiotics are the best known products of actinomycete. over 5,000 antibiotics have been identified from the cultures of gram positive and gram-negative organisms, and filamentous fungi, but only about 100 antibiotics have commercially been used to treat human, animal and plant diseases. the genus, streptomycete, is responsible for the formation of more than 60% of known antibiotics. bacterial...

a quasi. experimental study was conducted to investigate the antagonistic effect of flumazenil on the   recovery of patients above the age 50 year from anaesthesia receiving benzodiazepine products in one of   iran medical sciences university hospital's operating rooms .   a total of sixty middle aged patients were selected sequentially . thirty of them (12 females and 18 males )   were in...

The role of the obesity cytokine leptin in breast cancer progression has raised interest in interfering with leptin's actions as a valuable therapeutic strategy. Leptin interacts with its receptor through three different binding sites: I-III. Site I is crucial for the formation of an active leptin-leptin receptor complex and in its subsequent activation. Amino acids 39-42 (Leu-Asp-Phe-Ile- LDFI...

conclusions the results of the current study suggested that spinal anesthesia plus intravenous patient-controlled analgesia have the most favorable cardiac effects regarding postoperative levels of pro-bnp. results there was no difference between three groups for basic characteristics and variables and baseline pro-bnp levels; however, postoperative pro-bnp levels in groups a, b, and c were res...

coprological analysis is still commonly employed to diagnose human fasciolosis despite the fact that this method is not utterly reliable. by far serologic methods in this case hold more validity and reliability. the purpose of the present study was to evaluate a 35-mer peptide covering a preliminary epitope of cathepsin l1, a new purified antigen of fasciola hepatica, by igg-elisa method for di...

Angiogenesis is central to the growth of cancers and VEGFR-1/Flt-1 plays an important role during the neovascularization under pathological conditions. We previously founded a VEGFR1 antagonistic peptide, F56, by screening the phage peptide library. We showed that DHFR-F56 chimeric protein displayed anti-tumor activity and inhibited angiogenesis, however the anti-tumor activity of monomeric F56...

The EphB4 receptor tyrosine kinase together with its preferred ligand, ephrin-B2, regulates a variety of physiological and pathological processes, including tumor progression, pathological forms of angiogenesis, cardiomyocyte differentiation and bone remodeling. We previously reported the identification of TNYL-RAW, a 15 amino acid-long peptide that binds to the ephrin-binding pocked of EphB4 w...

UNLABELLED The glucagon-like peptide-1 (GLP-1) receptors are important biomarkers for imaging pancreatic β-cell mass and detection of benign insulinomas. Using GLP-1 receptor antagonists, we aimed to eliminate the insulin-related side effects reported for all GLP-1 receptor agonists. Additionally, using a nonresidualizing tracer, (125)I-Bolton-Hunter-Exendin(9-39)NH2 ((125)I-BH-Ex(9-39)NH2), we...

Purpose: The receptor for advanced glycation end products (RAGE) contributes tomultiple pathologies, including diabetes, arthritis, neurodegenerative diseases, and cancer. Despite the obvious need, no RAGE inhibitors are in common clinical use. Therefore, we developed a novel small RAGE antagonist peptide (RAP) that blocks activation by multiple ligands. Experimental Design: RAGE and its ligand...