It has long been recognized that heredity plays a part in the aetiology of glaucoma. Fran §ois and Heintz-de Bree (I966) postulated a dominant heredity in open-angle glaucoma. They noted a 98 per cent. penetrance for a dominant gene in some families, but admitted that in other families the penetrance for a dominant gene was very low. Armaly (i 967a), on the other hand, suggested a polygenic inh...

BACKGROUND Open-angle glaucoma appears to be induced by the malfunction of the trabecular meshwork cells due to injury induced by oxidative damage and mitochondrial impairment. Here, we report that, in fact, we have detected mitochondrial damage only in primary open-angle glaucoma and pseudo-exfoliation glaucoma, among several glaucoma types compared. METHODOLOGY/PRINCIPAL FINDINGS Mitochondr...

Trabeculectomy surgery is the current standard of care in glaucoma for achieving a low target intraocular pressure if medical therapy is not adequate. Augmentation of trabeculectomy with antimetabolites brought a revolutionary change in the long-term success rates of trabeculectomy, but along with it came a plethora of complications. There still is a big window for therapeutic innovations on th...

PURPOSE To evaluate and correlate the peaks and the fluctuation of intraocular pressure seen in the association of the ambulatory intraocular pressure curve with the water-drinking test versus the peaks and the fluctuation seen in the daily intraocular pressure curve. METHODS The sample was as follows: 77 eyes belonging to 77 patients who were divided into three groups composed of 31 eyes bel...

When Policy Topic is covered Canaloplasty may be considered medically necessary as a method to reduce intraocular pressure in patients with chronic primary open-angle glaucoma under the following conditions:  Medical therapy has failed to adequately control intraocular pressure, AND  The patient is not a candidate for any other intraocular pressure lowering procedure (e.g. trabeculectomy or g...

Glaucoma is a major blinding condition and is more prevalent amongst the elderly. A population study of 479 elderly Chinese aged 60 years and older, and residing in Singapore was carried out to determine the prevalence of glaucoma. The overall glaucoma prevalence was 4.8% with normal tension glaucoma (61%) and primary angle closure glaucoma (26%) being the most prevalent forms of glaucoma. All ...

PURPOSE To investigate biometrically the differences between plateau iris configuration (PIC) eyes and primary open angle glaucoma with narrow angle eyes. METHODS A comparative study involving a case series with 20 eyes of 11 plateau iris configuration patients and 45 eyes of 27 primary open angle glaucoma with narrow angle eyes patients was done. The following measurements were taken: cornea...

Purpose. The aim of this meta-analysis was to clarify the association between the plasma endothelin-1 level and the risks of normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG). Methods. Relevant publications were collected from three databases including PubMed, EMBASE, and the Web of Science through December 31, 2015. In this study, the terms "(endothelin OR ET) AND glaucoma" ...

Primary angle-closure glaucoma (PACG) frequently leads to severe vision loss. Prevalence among older Asian populations is high and given global demographics, the number of persons with PACG will increase dramatically in the coming decades. Improvements in imaging of the anterior segment will help us to identify more of those with angle closure, and important clinical trials that are currently u...