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The predictive strength of next-generation sequencing MRD detection for relapse compared with current methods in childhood ALL Minimal residual disease (MRD) monitoring via antigen receptor quantitative polymerase chain reaction (qPCR) is an important pre-dictor of outcome in childhood acute lymphoblastic leukemia (ALL), is rigorously standardized within the EuroMRD consortium and has a greater...
Patients with resected oral squamous cell carcinoma (OSCC) harboring extracapsular extension (ECE) of the involved lymph node, show poor and heterogeneous outcomes. We aim to improve their prognostic stratification by combining genetic information from next-generation sequencing (NGS) using traditional clinicopathological prognosticators. The hotspot mutation regions of 45 cancer-related genes ...
INTRODUCTION Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited heart disease. Next-generation sequencing (NGS) is the preferred genetic test, but the diagnostic value of screening for minor and candidate genes, and the role of copy number variants (CNVs) deserves further evaluation. METHODS Three hundred and eighty-seven consecutive unrelated patients with HCM were screened fo...
Obituary British dermatology and the Bristol medical community suffered a grievous loss on 1.7.92 when Bob and Anne warm vvere both killed in a car crash near Salisbury, while they were travelling to the Bournemouth Meeting of the British and he and Anne had been such central figures in the Association for so many years that it was difficult to believe he Meeting could continue in their absence...
There is a huge need for standardized analysis and statistical procedures in order to compare the complex immune repertoires of antigen receptors immunoglobulins (IG) and T cell receptors (TR) obtained by next generation sequencing (NGS). NGS technologies generate millions of nucleotide sequences and have led to the development of new tools. The IMGT/HighV-QUEST, available since 2010, is the fi...
Experience with the cmrent gelleration of astronomical single laser guide star (LGS) adaptive optics (AO) systellls has demoIlstrated systelll perforlIlance that is often lilllited by residual tip-tilt errors illduced by the paucity of bright tip-tilt natural guide stars (NCS). To overcollle this lilllitation, we are developillg a nt'w gelleration of tip-tilt sensors that will operate at near-i...
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