objective: β-thalassemia is caused by absence or reduction of β-globin chain synthesis. one of the effective therapeutic methods for this disease can be gene therapy by viral vectors. the capacity of lentiviral vectors is approximately 8 kb, we designed a 6 kb construct containing mini lcr and β-globin gene instead of lcr region. the aim of this study is to make a recombinant lentiviruses conta...

fasting, that is usually described as abstinence from all food and drink for a period of time, has been experienced for ages. health, protest, religious expressions of devotion and purification are the most important reasons for fasting. many changes occur in the body during fasting including metabolic, mineral, hormonal, immunological and psychological. its use as one of the oldest therapies a...

We investigate the problem of creating simplified representations of polygonal paths. Specifically, we look at a path simplification problem in which line segments of a simplification are required to conform with a restricted set of directions C. An algorithm is given to compute such simplified paths in O(|C|n) time, where n is the number of vertices in the original path. This result is extende...

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Abstract: The objective of this work was to evaluate the influence pruning management mini-stumps Climax blueberry cultivar, when weekly fertigated, on productivity clonal mini-garden and rooting root vigor mini-cuttings. high survival (100%) production mini-cuttings (182.9 per square meter month) evidence adaptability material successive samplings nutritional conditions provided mini-garden, r...

T C teel remains one of the most important manufacturing industries in Indiana, and the dominant manufacturing industry in Northwest Indiana. The Chicago region continues to lead the U.S. in steel production, accounting for as much as 28% of the total output of steel in the country.1 Currently, steel mill employment accounts for nearly 10% of total employment in Northwest Indiana,2 compared wit...

Abstract. We initiate a new problem of automatic metro map layout. In general, a metro map consists of a set of lines which have intersections or overlaps. We define a set of aesthetic criteria for good metro map layouts and present a method to produce such layouts automatically. Our method uses a variation of the spring algorithm with a suitable preprocessing step. The experimental results wit...

conclusions in the newly set up center similar to the older one, surgical treatment in our follow up duration was effective for reducing weight, body mass index reduction and achievement of success in biochemical markers on diabetics. results during follow up time after 276 days mean weight decreased from 118.7 ± 23.3 to 82.9 ± 15.7, p < 0.001 bmi also changed from 45.2 ± 1.8 to 32.2 ± 1.3, p <...