BACKGROUND Long-acting insulin analogues for type 1 diabetes (T1D) treatment have been available on the Brazilian market since 2002. However, the population cannot access the analogues through the public health system. OBJECTIVE To estimate the incremental budget impact of long-acting insulin analogues coverage for T1D patients in the Brazilian public health system compared to NPH insulin. ...

A new method to measure nonlinear dependence between two variables is described using mutual information to analyze the separate linear and nonlinear components of dependence. This technique, which gives an exact value for the proportion of linear dependence, is then compared with another common test for linearity, the Brock, Dechert and Scheinkman (BDS) test. Copyright c © 0000 John Wiley & So...

This paper introduces a new type of intranet – the compliance intranet – and describes its socio-technical shaping. Compliance intranets serve to enforce industry standards, to measure the performance of a company against industry or governmentally established standards, or to establish standards within the organization or within a larger domain. These intranets may be quality management system...

In a survey we found that most developers have experienced duplicated bug reports, however, only few considered them as a serious problem. This contradicts popular wisdom that considers bug duplicates as a serious problem for open source projects. In the survey, developers also pointed out that the additional information provided by duplicates helps to resolve bugs quicker. In this paper, we th...

As the component parameters of analog circuits are influenced by tolerance, a soft fault-concept diagnosis model in this paper, which is based on the qualitative concepts of cloud model theory, is proposed to achieve the complete description of fault states and the fast diagnosis. The diagnosis model uses the cloud transform method to represent the conceptual soft classification of the multiple...

gonadotropin releasing hormone (gnrh) plays a key role in reproduction. this decapeptide is synthesized and released by hypothalamus and induces the pituitary gonadotrop cells to release pituitary gonadotropin hormones. in some extrapituitary compartments gnrh and its receptor act as part of the autocrine regulatory system of cell proliferation. the anticancer activity of gnrh and its analogues...

driver fatigue is one of the main causes of road accidents. this study aimed to estimate bus driver fatigue through performance measures in a virtual driving environment. the study was conducted on thirty professional male bus drivers participated in a two-hour drive session. the driver subjective fatigue was assessed by fatigue visual analogue scale (f-vas) on 10 min intervals. at the same tim...

a b s t r a c tintroduction: although decision-making processes have become a principal target of study among addiction researchers, few researches are published according to effects of different treatment methods on the cognitive processes underlying decision making up to now. utilizing cognitive modeling method, in this paper we examine the effects of methadone maintenance treatment (mmt) on ...

The growth of manufacturing was central to the economic development of nineteenth century America. In the early stages of industrialization, the commitment to produce was frequently seasonal or part-time, and establishments might shut down operations for weeks or months at a time. But, as transportation improved and markets widened in their geographic scope and, as technological and organizatio...

The concept of offshoring of professional services first gained attention slightly over 25 years ago. At that time, US companies began to realize the cost-advantage of getting their computer software developed in India and other countries. The concept gained momentum with the advent of Internet and the availability of inexpensive communication technologies. Unrelated events, such as the need to...