A randomized study was performed to assess the effect of topical 1% amethocaine hydrochloride on postoperative analgesia requirements after strabismus surgery. Forty children scheduled for elective operation were allocated randomly to receive either topical amethocaine or normal saline. Postoperative analgesia was evaluated with the use of a four-point assessment score and analgesic requirement...

BACKGROUND Polypharmacological approach is the most common practice to treat perioperative pain, as no single agent has yet been identified to specifically inhibit nociception without associated side effects. Opioids such as Fentanyl is commonly added to local anesthetics to produce spinal and epidural anesthesia. However, significant adverse effects, such as pruritus, respiratory depression, h...

Study Objective: This study was designed to evaluate the effect of preemptive use of intravenous acetaminophen, ketamine or their combination on intraoperative and postoperative analgesic requirements in patients undergoing elective open abdominal and urological surgeries under general anesthesia. Setting: Beni Suef University Hospital, Egypt. Patients and Interventions: 80 ASA I-II patients un...

PCA (Patient Controlled Analgesia) is a delivery system for pain medication that makes effective and flexible pain treatments possible by allowing patients to adjust the dosage of analgesics themselves. Unlike previous research on patient controlled analgesia, this study explores patient demand behavior over time. We applied clustering methods to disclose demand patterns among patients over the...

Unlike previous research on patient controlled analgesia, this study explores patient demand behavior over time. We apply clustering methods to disclose demand patterns among patients over the first 24h of analgesic medication after surgery. We consider demographic, biomedical, and surgery-related data in statistical analyses to determine predictors for patient demand behavior, and use stepwise...

This study evaluates the effect of oral pancreatic enzyme supplements on pain, analgesic requirement and the incidence of complications in patients with acute pancreatitis. This double blind, prospectively randomised placebo controlled study included 23 patients. Pain was monitored using a visual analogue scale; the analgesic requirement was assessed with a numerical score. No significant diffe...

Intra-articular morphine has been shown to provide prolonged analgesia after arthroscopic knee surgery; the addition of local anaesthetic agents has been reported to improve this analgesic effect. Pethidine possesses local anaesthetic properties, and therefore this study was designed to evaluate its analgesic efficacy after arthroscopic meniscectomy. Sixty patients were allocated randomly to re...

In recent years, there has been an increasing interest in local infiltration analgesia (LIA) as a technique to control postoperative pain. We conducted a systematic review of randomized clinical trials investigating LIA for total knee arthroplasty (TKA) and total hip arthroplasty (THA) to evaluate the analgesic efficacy of LIA for early postoperative pain treatment. In addition, the analgesic e...

Two common forms of postoperative analgesia used in patients following an anterior cruciate ligament repair (ACLR) are the femoral nerve block (FNB) and the combined femoral-sciatic nerve block (FSB). The purpose of this study was to determine if the addition of the sciatic nerve block to the FNB is truly beneficial in ACLR patients requesting regional anesthesia for postoperative pain control....

BACKGROUND Psychological factors are thought to drive inter-patient variations in anaesthetic and analgesic requirements. This cross-sectional study investigated whether preoperative psychological factors can predict anaesthetic requirements and postoperative pain. METHODS Before total thyroidectomy, 100 consecutive women completed the Spielberger's State-Trait Anxiety Inventory (STAI) and th...